Lead identification and optimization of novel collagenase inhibitors; pharmacophore and structure based studies

In this study, chemical feature based pharmacophore models of MMP-1, MMP-8 and MMP-13 inhibitors have been developed with the aid of HypoGen module within Catalyst program package. In MMP-1 and MMP-13, all the compounds in the training set mapped HBA and RA, while in MMP-8, the training set mapped H...

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Detalles Bibliográficos
Autores principales: Kalva, Sukesh, Vadivelan, S, Sanam, Ramadevi, Jagarlapudi, Sarma ARP, Saleena, Lilly M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2012
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338973/
https://www.ncbi.nlm.nih.gov/pubmed/22553386
http://dx.doi.org/10.6026/97320630008301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338973/
https://www.ncbi.nlm.nih.gov/pubmed/22553386
http://dx.doi.org/10.6026/97320630008301

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