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Pirfenidone inhibits transforming growth factor-β1-induced fibrogenesis by blocking nuclear translocation of Smads in human retinal pigment epithelial cell line ARPE-19

PURPOSE: Transforming growth factor-β (TGF-β) plays a key role in transforming retinal pigment epithelial (RPE) cells into mesenchymal fibroblastic cells, which are implicated in proliferative vitreoretinopathy. Herein, we tested the effect of pirfenidone, a novel antifibrotic agent, on TGF-β1-media...

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Detalles Bibliográficos
Autores principales:	Choi, Kyungsun, Lee, Kihwang, Ryu, Seung-Wook, Im, Minju, Kook, Koung Hoon, Choi, Chulhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Vision 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339036/ https://www.ncbi.nlm.nih.gov/pubmed/22550395

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