Determination of Vitamin A and its Metabolites in Rat Testis: Possible Involvement of Vitamin A in Testicular Toxicity Caused by Molinate

This study was conducted to evaluate the effect of molinate on retinoids homeostasis in rat testis. Molinate was administrated to male Sprague–Dawley rats (200 mg kg(−1) in corn oil, ip). Retinoid measurements were made at 6, 12, 48 and 168 h time points after administration. Testis levels of retino...

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Autores principales: Zuno-Floriano, Fabiola G., Holstege, Dirk, Hengel, Matt J., Gaikwad, Nilesh W., Aldana-Madrid, Maria L., Miller, Marion G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339053/
https://www.ncbi.nlm.nih.gov/pubmed/22456730
http://dx.doi.org/10.1007/s00128-012-0612-0
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author Zuno-Floriano, Fabiola G.
Holstege, Dirk
Hengel, Matt J.
Gaikwad, Nilesh W.
Aldana-Madrid, Maria L.
Miller, Marion G.
author_facet Zuno-Floriano, Fabiola G.
Holstege, Dirk
Hengel, Matt J.
Gaikwad, Nilesh W.
Aldana-Madrid, Maria L.
Miller, Marion G.
author_sort Zuno-Floriano, Fabiola G.
collection PubMed
description This study was conducted to evaluate the effect of molinate on retinoids homeostasis in rat testis. Molinate was administrated to male Sprague–Dawley rats (200 mg kg(−1) in corn oil, ip). Retinoid measurements were made at 6, 12, 48 and 168 h time points after administration. Testis levels of retinoic acid decreased (32 %) in a statistically significant manner at the 12 and 48 h time points. However, retinol and retinaldehyde were not significantly affected by molinate. These results suggest that molinate affects retinoic acid synthesis in testis and could contribute to understanding the molecular mechanism of molinate involved testicular toxicity.
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spelling pubmed-33390532012-05-16 Determination of Vitamin A and its Metabolites in Rat Testis: Possible Involvement of Vitamin A in Testicular Toxicity Caused by Molinate Zuno-Floriano, Fabiola G. Holstege, Dirk Hengel, Matt J. Gaikwad, Nilesh W. Aldana-Madrid, Maria L. Miller, Marion G. Bull Environ Contam Toxicol Article This study was conducted to evaluate the effect of molinate on retinoids homeostasis in rat testis. Molinate was administrated to male Sprague–Dawley rats (200 mg kg(−1) in corn oil, ip). Retinoid measurements were made at 6, 12, 48 and 168 h time points after administration. Testis levels of retinoic acid decreased (32 %) in a statistically significant manner at the 12 and 48 h time points. However, retinol and retinaldehyde were not significantly affected by molinate. These results suggest that molinate affects retinoic acid synthesis in testis and could contribute to understanding the molecular mechanism of molinate involved testicular toxicity. Springer-Verlag 2012-03-29 2012 /pmc/articles/PMC3339053/ /pubmed/22456730 http://dx.doi.org/10.1007/s00128-012-0612-0 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Article
Zuno-Floriano, Fabiola G.
Holstege, Dirk
Hengel, Matt J.
Gaikwad, Nilesh W.
Aldana-Madrid, Maria L.
Miller, Marion G.
Determination of Vitamin A and its Metabolites in Rat Testis: Possible Involvement of Vitamin A in Testicular Toxicity Caused by Molinate
title Determination of Vitamin A and its Metabolites in Rat Testis: Possible Involvement of Vitamin A in Testicular Toxicity Caused by Molinate
title_full Determination of Vitamin A and its Metabolites in Rat Testis: Possible Involvement of Vitamin A in Testicular Toxicity Caused by Molinate
title_fullStr Determination of Vitamin A and its Metabolites in Rat Testis: Possible Involvement of Vitamin A in Testicular Toxicity Caused by Molinate
title_full_unstemmed Determination of Vitamin A and its Metabolites in Rat Testis: Possible Involvement of Vitamin A in Testicular Toxicity Caused by Molinate
title_short Determination of Vitamin A and its Metabolites in Rat Testis: Possible Involvement of Vitamin A in Testicular Toxicity Caused by Molinate
title_sort determination of vitamin a and its metabolites in rat testis: possible involvement of vitamin a in testicular toxicity caused by molinate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339053/
https://www.ncbi.nlm.nih.gov/pubmed/22456730
http://dx.doi.org/10.1007/s00128-012-0612-0
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