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Post-natal maternal antiretroviral therapy and HIV prevalence among breast-fed infants in Benin, Nigeria
BACKGROUND: Breastfeeding is an established mode of transmission of human immunodeficiency virus (HIV) infection resulting in clash between socio-cultural values and medical practice. AIMS: This study aims to determine the effect of post-natal maternal antiretroviral therapy on transmission of HIV t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339101/ https://www.ncbi.nlm.nih.gov/pubmed/22558591 http://dx.doi.org/10.4297/najms.2010.2427 |
Sumario: | BACKGROUND: Breastfeeding is an established mode of transmission of human immunodeficiency virus (HIV) infection resulting in clash between socio-cultural values and medical practice. AIMS: This study aims to determine the effect of post-natal maternal antiretroviral therapy on transmission of HIV through breastfeeding. PATIENTS AND METHODS: A total of 318 pregnant women were followed from pregnancy to 6 months post- partum. The women were divided into breast-fed and those who did not breast-feed, while the breast-fed were further divided into those on antiretroviral (ARV) and those not on ARV. After 6 months post-partum, dried blood spots were collected from infants born to these women and tested for HIV using polymerase chain reaction. RESULTS: Generally, breast-feeding had 4 to 13 fold increase risk of transmission of HIV to infants (OR =7.079 95% CI = 3.768, 13.300; P <0.0001). However, among breast-fed infants, post-natal maternal ARV resulted in reduced prevalence of HIV compared to mothers who did not use ARV during breast-feeding (17.31% VS 92.00%; P<0.0001). CONCLUSION: The study demonstrates the effectiveness of post–natal maternal ARV. However, research into better feeding options to prevent mother to child transmission of HIV via breast-feeding is advocated. |
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