Cargando…

Post-natal maternal antiretroviral therapy and HIV prevalence among breast-fed infants in Benin, Nigeria

BACKGROUND: Breastfeeding is an established mode of transmission of human immunodeficiency virus (HIV) infection resulting in clash between socio-cultural values and medical practice. AIMS: This study aims to determine the effect of post-natal maternal antiretroviral therapy on transmission of HIV t...

Descripción completa

Detalles Bibliográficos
Autores principales: Imade, Paul E., Uwakwe, Nkemjika O., Omoregie, Richard, Eghafona, Nosakhare O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339101/
https://www.ncbi.nlm.nih.gov/pubmed/22558591
http://dx.doi.org/10.4297/najms.2010.2427
_version_ 1782231306393878528
author Imade, Paul E.
Uwakwe, Nkemjika O.
Omoregie, Richard
Eghafona, Nosakhare O.
author_facet Imade, Paul E.
Uwakwe, Nkemjika O.
Omoregie, Richard
Eghafona, Nosakhare O.
author_sort Imade, Paul E.
collection PubMed
description BACKGROUND: Breastfeeding is an established mode of transmission of human immunodeficiency virus (HIV) infection resulting in clash between socio-cultural values and medical practice. AIMS: This study aims to determine the effect of post-natal maternal antiretroviral therapy on transmission of HIV through breastfeeding. PATIENTS AND METHODS: A total of 318 pregnant women were followed from pregnancy to 6 months post- partum. The women were divided into breast-fed and those who did not breast-feed, while the breast-fed were further divided into those on antiretroviral (ARV) and those not on ARV. After 6 months post-partum, dried blood spots were collected from infants born to these women and tested for HIV using polymerase chain reaction. RESULTS: Generally, breast-feeding had 4 to 13 fold increase risk of transmission of HIV to infants (OR =7.079 95% CI = 3.768, 13.300; P <0.0001). However, among breast-fed infants, post-natal maternal ARV resulted in reduced prevalence of HIV compared to mothers who did not use ARV during breast-feeding (17.31% VS 92.00%; P<0.0001). CONCLUSION: The study demonstrates the effectiveness of post–natal maternal ARV. However, research into better feeding options to prevent mother to child transmission of HIV via breast-feeding is advocated.
format Online
Article
Text
id pubmed-3339101
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-33391012012-05-03 Post-natal maternal antiretroviral therapy and HIV prevalence among breast-fed infants in Benin, Nigeria Imade, Paul E. Uwakwe, Nkemjika O. Omoregie, Richard Eghafona, Nosakhare O. N Am J Med Sci Original Article BACKGROUND: Breastfeeding is an established mode of transmission of human immunodeficiency virus (HIV) infection resulting in clash between socio-cultural values and medical practice. AIMS: This study aims to determine the effect of post-natal maternal antiretroviral therapy on transmission of HIV through breastfeeding. PATIENTS AND METHODS: A total of 318 pregnant women were followed from pregnancy to 6 months post- partum. The women were divided into breast-fed and those who did not breast-feed, while the breast-fed were further divided into those on antiretroviral (ARV) and those not on ARV. After 6 months post-partum, dried blood spots were collected from infants born to these women and tested for HIV using polymerase chain reaction. RESULTS: Generally, breast-feeding had 4 to 13 fold increase risk of transmission of HIV to infants (OR =7.079 95% CI = 3.768, 13.300; P <0.0001). However, among breast-fed infants, post-natal maternal ARV resulted in reduced prevalence of HIV compared to mothers who did not use ARV during breast-feeding (17.31% VS 92.00%; P<0.0001). CONCLUSION: The study demonstrates the effectiveness of post–natal maternal ARV. However, research into better feeding options to prevent mother to child transmission of HIV via breast-feeding is advocated. Medknow Publications & Media Pvt Ltd 2010-09 /pmc/articles/PMC3339101/ /pubmed/22558591 http://dx.doi.org/10.4297/najms.2010.2427 Text en Copyright: © North American Journal of Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Imade, Paul E.
Uwakwe, Nkemjika O.
Omoregie, Richard
Eghafona, Nosakhare O.
Post-natal maternal antiretroviral therapy and HIV prevalence among breast-fed infants in Benin, Nigeria
title Post-natal maternal antiretroviral therapy and HIV prevalence among breast-fed infants in Benin, Nigeria
title_full Post-natal maternal antiretroviral therapy and HIV prevalence among breast-fed infants in Benin, Nigeria
title_fullStr Post-natal maternal antiretroviral therapy and HIV prevalence among breast-fed infants in Benin, Nigeria
title_full_unstemmed Post-natal maternal antiretroviral therapy and HIV prevalence among breast-fed infants in Benin, Nigeria
title_short Post-natal maternal antiretroviral therapy and HIV prevalence among breast-fed infants in Benin, Nigeria
title_sort post-natal maternal antiretroviral therapy and hiv prevalence among breast-fed infants in benin, nigeria
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339101/
https://www.ncbi.nlm.nih.gov/pubmed/22558591
http://dx.doi.org/10.4297/najms.2010.2427
work_keys_str_mv AT imadepaule postnatalmaternalantiretroviraltherapyandhivprevalenceamongbreastfedinfantsinbeninnigeria
AT uwakwenkemjikao postnatalmaternalantiretroviraltherapyandhivprevalenceamongbreastfedinfantsinbeninnigeria
AT omoregierichard postnatalmaternalantiretroviraltherapyandhivprevalenceamongbreastfedinfantsinbeninnigeria
AT eghafonanosakhareo postnatalmaternalantiretroviraltherapyandhivprevalenceamongbreastfedinfantsinbeninnigeria