[3 + 2] Cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid: a versatile route to new heterocyclic scaffolds

A facile synthesis of azabicycloadducts is described by 1,3-dipolar cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid in the presence of various electron rich and electron deficient dipolarophiles. Theoritical calculations have been performed to study the regioselectivity of...

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Autores principales: Verma, Sonali, George, Johnson, Singh, Saurabh, Pardasani, Pushpa, Pardasani, Ramchand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2011
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339372/
https://www.ncbi.nlm.nih.gov/pubmed/22373364
http://dx.doi.org/10.1186/2191-2858-1-6
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author Verma, Sonali
George, Johnson
Singh, Saurabh
Pardasani, Pushpa
Pardasani, Ramchand
author_facet Verma, Sonali
George, Johnson
Singh, Saurabh
Pardasani, Pushpa
Pardasani, Ramchand
author_sort Verma, Sonali
collection PubMed
description A facile synthesis of azabicycloadducts is described by 1,3-dipolar cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid in the presence of various electron rich and electron deficient dipolarophiles. Theoritical calculations have been performed to study the regioselectivity of products. The geometrical and energetic properties have been analyzed for the different reactants, transition states and cycloadducts formed.
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spelling pubmed-33393722012-04-30 [3 + 2] Cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid: a versatile route to new heterocyclic scaffolds Verma, Sonali George, Johnson Singh, Saurabh Pardasani, Pushpa Pardasani, Ramchand Org Med Chem Lett Original A facile synthesis of azabicycloadducts is described by 1,3-dipolar cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid in the presence of various electron rich and electron deficient dipolarophiles. Theoritical calculations have been performed to study the regioselectivity of products. The geometrical and energetic properties have been analyzed for the different reactants, transition states and cycloadducts formed. Springer 2011-09-06 /pmc/articles/PMC3339372/ /pubmed/22373364 http://dx.doi.org/10.1186/2191-2858-1-6 Text en Copyright © 2011 Verma et al; licensee Springer. https://creativecommons.org/licenses/by/2.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0 (https://creativecommons.org/licenses/by/2.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original
Verma, Sonali
George, Johnson
Singh, Saurabh
Pardasani, Pushpa
Pardasani, Ramchand
[3 + 2] Cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid: a versatile route to new heterocyclic scaffolds
title [3 + 2] Cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid: a versatile route to new heterocyclic scaffolds
title_full [3 + 2] Cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid: a versatile route to new heterocyclic scaffolds
title_fullStr [3 + 2] Cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid: a versatile route to new heterocyclic scaffolds
title_full_unstemmed [3 + 2] Cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid: a versatile route to new heterocyclic scaffolds
title_short [3 + 2] Cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid: a versatile route to new heterocyclic scaffolds
title_sort [3 + 2] cycloaddition reactions of thioisatin with thiazolidine-2-carboxylic acid: a versatile route to new heterocyclic scaffolds
topic Original
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339372/
https://www.ncbi.nlm.nih.gov/pubmed/22373364
http://dx.doi.org/10.1186/2191-2858-1-6
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