Cargando…

An Association Study of Interleukin 18 Receptor Genes (IL18R1 and IL18RAP) in Lumbar Disc Degeneration

OBJECTIVES: To examine association of candidate genetic variants in structural, inflammatory, matrix modifying, vitamin D receptor genes and variants associated with osteoarthritis, with surgical candidates and surgical patients with lumbar disc degeneration (LDD), in light of their previously repor...

Descripción completa

Detalles Bibliográficos
Autores principales: Omair, Ahmad, Lie, Benedicte Alexandra, Reikeras, Olav, Brox, Jens Ivar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339430/
https://www.ncbi.nlm.nih.gov/pubmed/22550553
http://dx.doi.org/10.2174/1874325001206010164
_version_ 1782231356301901824
author Omair, Ahmad
Lie, Benedicte Alexandra
Reikeras, Olav
Brox, Jens Ivar
author_facet Omair, Ahmad
Lie, Benedicte Alexandra
Reikeras, Olav
Brox, Jens Ivar
author_sort Omair, Ahmad
collection PubMed
description OBJECTIVES: To examine association of candidate genetic variants in structural, inflammatory, matrix modifying, vitamin D receptor genes and variants associated with osteoarthritis, with surgical candidates and surgical patients with lumbar disc degeneration (LDD), in light of their previously reported susceptibility for LDD. METHODS: Genotyping of 146 Norwegian LDD patients and 188 Norwegian controls was performed for 20 single-nucleotide polymorphisms (SNPs) from collagen, aggrecan, interleukin, VDR, MMP3 and COX2 genes and 7 SNPs from osteoarthritic genes. RESULTS: The neighboring genes IL18R1 and IL18RAP polymorphisms (rs2287037 and rs1420100), showed a statistically non-significant risk for developing LDD (OR 1.36 [95 % CI 0.99 – 1.87]; p=0.06 and OR 1.33 [95 % CI 0.98-1.81]; p=0.07). Homozygosity of these risk alleles was associated with LDD (p=0.023 and p=0.027). The non-risk alleles at these SNPs were situated on a haplotype negatively associated with LDD (p=0.008). Carriage of at least one non-risk allele at both loci also reduces the risk of developing LDD (OR 0.51 [95 % CI 0.33-0.80]; p=0.003). CONCLUSION: Our findings support the polygenic nature of LDD and suggest that variation in interleukin 18 receptor genes could affect the risk of severe LDD and associated low back pain.
format Online
Article
Text
id pubmed-3339430
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Bentham Open
record_format MEDLINE/PubMed
spelling pubmed-33394302012-05-01 An Association Study of Interleukin 18 Receptor Genes (IL18R1 and IL18RAP) in Lumbar Disc Degeneration Omair, Ahmad Lie, Benedicte Alexandra Reikeras, Olav Brox, Jens Ivar Open Orthop J Article OBJECTIVES: To examine association of candidate genetic variants in structural, inflammatory, matrix modifying, vitamin D receptor genes and variants associated with osteoarthritis, with surgical candidates and surgical patients with lumbar disc degeneration (LDD), in light of their previously reported susceptibility for LDD. METHODS: Genotyping of 146 Norwegian LDD patients and 188 Norwegian controls was performed for 20 single-nucleotide polymorphisms (SNPs) from collagen, aggrecan, interleukin, VDR, MMP3 and COX2 genes and 7 SNPs from osteoarthritic genes. RESULTS: The neighboring genes IL18R1 and IL18RAP polymorphisms (rs2287037 and rs1420100), showed a statistically non-significant risk for developing LDD (OR 1.36 [95 % CI 0.99 – 1.87]; p=0.06 and OR 1.33 [95 % CI 0.98-1.81]; p=0.07). Homozygosity of these risk alleles was associated with LDD (p=0.023 and p=0.027). The non-risk alleles at these SNPs were situated on a haplotype negatively associated with LDD (p=0.008). Carriage of at least one non-risk allele at both loci also reduces the risk of developing LDD (OR 0.51 [95 % CI 0.33-0.80]; p=0.003). CONCLUSION: Our findings support the polygenic nature of LDD and suggest that variation in interleukin 18 receptor genes could affect the risk of severe LDD and associated low back pain. Bentham Open 2012-04-20 /pmc/articles/PMC3339430/ /pubmed/22550553 http://dx.doi.org/10.2174/1874325001206010164 Text en © Omair et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Omair, Ahmad
Lie, Benedicte Alexandra
Reikeras, Olav
Brox, Jens Ivar
An Association Study of Interleukin 18 Receptor Genes (IL18R1 and IL18RAP) in Lumbar Disc Degeneration
title An Association Study of Interleukin 18 Receptor Genes (IL18R1 and IL18RAP) in Lumbar Disc Degeneration
title_full An Association Study of Interleukin 18 Receptor Genes (IL18R1 and IL18RAP) in Lumbar Disc Degeneration
title_fullStr An Association Study of Interleukin 18 Receptor Genes (IL18R1 and IL18RAP) in Lumbar Disc Degeneration
title_full_unstemmed An Association Study of Interleukin 18 Receptor Genes (IL18R1 and IL18RAP) in Lumbar Disc Degeneration
title_short An Association Study of Interleukin 18 Receptor Genes (IL18R1 and IL18RAP) in Lumbar Disc Degeneration
title_sort association study of interleukin 18 receptor genes (il18r1 and il18rap) in lumbar disc degeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339430/
https://www.ncbi.nlm.nih.gov/pubmed/22550553
http://dx.doi.org/10.2174/1874325001206010164
work_keys_str_mv AT omairahmad anassociationstudyofinterleukin18receptorgenesil18r1andil18rapinlumbardiscdegeneration
AT liebenedictealexandra anassociationstudyofinterleukin18receptorgenesil18r1andil18rapinlumbardiscdegeneration
AT reikerasolav anassociationstudyofinterleukin18receptorgenesil18r1andil18rapinlumbardiscdegeneration
AT broxjensivar anassociationstudyofinterleukin18receptorgenesil18r1andil18rapinlumbardiscdegeneration
AT omairahmad associationstudyofinterleukin18receptorgenesil18r1andil18rapinlumbardiscdegeneration
AT liebenedictealexandra associationstudyofinterleukin18receptorgenesil18r1andil18rapinlumbardiscdegeneration
AT reikerasolav associationstudyofinterleukin18receptorgenesil18r1andil18rapinlumbardiscdegeneration
AT broxjensivar associationstudyofinterleukin18receptorgenesil18r1andil18rapinlumbardiscdegeneration