Kim-1/Tim-1 and Immune cells: Shifting Sands

Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory molecule for immune cells, its potential immunological role has been contr...

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Detalles Bibliográficos
Autores principales: Ichimura, Takaharu, Brooks, Craig R., Bonventre, Joseph V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339439/
https://www.ncbi.nlm.nih.gov/pubmed/22499138
http://dx.doi.org/10.1038/ki.2012.11
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author Ichimura, Takaharu
Brooks, Craig R.
Bonventre, Joseph V.
author_facet Ichimura, Takaharu
Brooks, Craig R.
Bonventre, Joseph V.
author_sort Ichimura, Takaharu
collection PubMed
description Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory molecule for immune cells, its potential immunological role has been controversial. In the presence of very high epithelial cell expression understanding the influence of immune cell Kim-1/Tim-1 expression in kidney injury relies on a better definition of its functional significance in immune cells and better characterization of antibodies used to probe function.
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spelling pubmed-33394392012-11-01 Kim-1/Tim-1 and Immune cells: Shifting Sands Ichimura, Takaharu Brooks, Craig R. Bonventre, Joseph V. Kidney Int Article Kim-1/Tim-1 is an apoptotic-cell phagocytosis and scavenger receptor that is most highly upregulated in proximal tubular epithelium in acute and chronic kidney injury. While Kim-1/Tim-1 has been proposed to be a costimulatory molecule for immune cells, its potential immunological role has been controversial. In the presence of very high epithelial cell expression understanding the influence of immune cell Kim-1/Tim-1 expression in kidney injury relies on a better definition of its functional significance in immune cells and better characterization of antibodies used to probe function. 2012-05 /pmc/articles/PMC3339439/ /pubmed/22499138 http://dx.doi.org/10.1038/ki.2012.11 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ichimura, Takaharu
Brooks, Craig R.
Bonventre, Joseph V.
Kim-1/Tim-1 and Immune cells: Shifting Sands
title Kim-1/Tim-1 and Immune cells: Shifting Sands
title_full Kim-1/Tim-1 and Immune cells: Shifting Sands
title_fullStr Kim-1/Tim-1 and Immune cells: Shifting Sands
title_full_unstemmed Kim-1/Tim-1 and Immune cells: Shifting Sands
title_short Kim-1/Tim-1 and Immune cells: Shifting Sands
title_sort kim-1/tim-1 and immune cells: shifting sands
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339439/
https://www.ncbi.nlm.nih.gov/pubmed/22499138
http://dx.doi.org/10.1038/ki.2012.11
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