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Tumor-promoting functions of transforming growth factor-β in progression of cancer

Transforming growth factor-β (TGF-β) elicits both tumor-suppressive and tumor-promoting functions during cancer progression. Here, we describe the tumor-promoting functions of TGF-β and how these functions play a role in cancer progression. Normal epithelial cells undergo epithelial-mesenchymal tran...

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Detalles Bibliográficos
Autores principales: Miyazono, Kohei, Ehata, Shogo, Koinuma, Daizo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339546/
https://www.ncbi.nlm.nih.gov/pubmed/22111550
http://dx.doi.org/10.3109/03009734.2011.638729
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author Miyazono, Kohei
Ehata, Shogo
Koinuma, Daizo
author_facet Miyazono, Kohei
Ehata, Shogo
Koinuma, Daizo
author_sort Miyazono, Kohei
collection PubMed
description Transforming growth factor-β (TGF-β) elicits both tumor-suppressive and tumor-promoting functions during cancer progression. Here, we describe the tumor-promoting functions of TGF-β and how these functions play a role in cancer progression. Normal epithelial cells undergo epithelial-mesenchymal transition (EMT) through the action of TGF-β, while treatment with TGF-β and fibroblast growth factor (FGF)-2 results in transdifferentiation into activated fibroblastic cells that are highly migratory, thereby facilitating cancer invasion and metastasis. TGF-β also induces EMT in tumor cells, which can be regulated by oncogenic and anti-oncogenic signals. In addition to EMT promotion, invasion and metastasis of cancer are facilitated by TGF-β through other mechanisms, such as regulation of cell survival, angiogenesis, and vascular integrity, and interaction with the tumor microenvironment. TGF-β also plays a critical role in regulating the cancer-initiating properties of certain types of cells, including glioma-initiating cells. These findings thus may be useful for establishing treatment strategies for advanced cancer by inhibiting TGF-β signaling.
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spelling pubmed-33395462012-05-24 Tumor-promoting functions of transforming growth factor-β in progression of cancer Miyazono, Kohei Ehata, Shogo Koinuma, Daizo Ups J Med Sci Review Article Transforming growth factor-β (TGF-β) elicits both tumor-suppressive and tumor-promoting functions during cancer progression. Here, we describe the tumor-promoting functions of TGF-β and how these functions play a role in cancer progression. Normal epithelial cells undergo epithelial-mesenchymal transition (EMT) through the action of TGF-β, while treatment with TGF-β and fibroblast growth factor (FGF)-2 results in transdifferentiation into activated fibroblastic cells that are highly migratory, thereby facilitating cancer invasion and metastasis. TGF-β also induces EMT in tumor cells, which can be regulated by oncogenic and anti-oncogenic signals. In addition to EMT promotion, invasion and metastasis of cancer are facilitated by TGF-β through other mechanisms, such as regulation of cell survival, angiogenesis, and vascular integrity, and interaction with the tumor microenvironment. TGF-β also plays a critical role in regulating the cancer-initiating properties of certain types of cells, including glioma-initiating cells. These findings thus may be useful for establishing treatment strategies for advanced cancer by inhibiting TGF-β signaling. Informa Healthcare 2012-05 2012-04-19 /pmc/articles/PMC3339546/ /pubmed/22111550 http://dx.doi.org/10.3109/03009734.2011.638729 Text en © Informa Healthcare http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Review Article
Miyazono, Kohei
Ehata, Shogo
Koinuma, Daizo
Tumor-promoting functions of transforming growth factor-β in progression of cancer
title Tumor-promoting functions of transforming growth factor-β in progression of cancer
title_full Tumor-promoting functions of transforming growth factor-β in progression of cancer
title_fullStr Tumor-promoting functions of transforming growth factor-β in progression of cancer
title_full_unstemmed Tumor-promoting functions of transforming growth factor-β in progression of cancer
title_short Tumor-promoting functions of transforming growth factor-β in progression of cancer
title_sort tumor-promoting functions of transforming growth factor-β in progression of cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339546/
https://www.ncbi.nlm.nih.gov/pubmed/22111550
http://dx.doi.org/10.3109/03009734.2011.638729
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