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Tumor-promoting functions of transforming growth factor-β in progression of cancer
Transforming growth factor-β (TGF-β) elicits both tumor-suppressive and tumor-promoting functions during cancer progression. Here, we describe the tumor-promoting functions of TGF-β and how these functions play a role in cancer progression. Normal epithelial cells undergo epithelial-mesenchymal tran...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Informa Healthcare
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339546/ https://www.ncbi.nlm.nih.gov/pubmed/22111550 http://dx.doi.org/10.3109/03009734.2011.638729 |
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author | Miyazono, Kohei Ehata, Shogo Koinuma, Daizo |
author_facet | Miyazono, Kohei Ehata, Shogo Koinuma, Daizo |
author_sort | Miyazono, Kohei |
collection | PubMed |
description | Transforming growth factor-β (TGF-β) elicits both tumor-suppressive and tumor-promoting functions during cancer progression. Here, we describe the tumor-promoting functions of TGF-β and how these functions play a role in cancer progression. Normal epithelial cells undergo epithelial-mesenchymal transition (EMT) through the action of TGF-β, while treatment with TGF-β and fibroblast growth factor (FGF)-2 results in transdifferentiation into activated fibroblastic cells that are highly migratory, thereby facilitating cancer invasion and metastasis. TGF-β also induces EMT in tumor cells, which can be regulated by oncogenic and anti-oncogenic signals. In addition to EMT promotion, invasion and metastasis of cancer are facilitated by TGF-β through other mechanisms, such as regulation of cell survival, angiogenesis, and vascular integrity, and interaction with the tumor microenvironment. TGF-β also plays a critical role in regulating the cancer-initiating properties of certain types of cells, including glioma-initiating cells. These findings thus may be useful for establishing treatment strategies for advanced cancer by inhibiting TGF-β signaling. |
format | Online Article Text |
id | pubmed-3339546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Informa Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-33395462012-05-24 Tumor-promoting functions of transforming growth factor-β in progression of cancer Miyazono, Kohei Ehata, Shogo Koinuma, Daizo Ups J Med Sci Review Article Transforming growth factor-β (TGF-β) elicits both tumor-suppressive and tumor-promoting functions during cancer progression. Here, we describe the tumor-promoting functions of TGF-β and how these functions play a role in cancer progression. Normal epithelial cells undergo epithelial-mesenchymal transition (EMT) through the action of TGF-β, while treatment with TGF-β and fibroblast growth factor (FGF)-2 results in transdifferentiation into activated fibroblastic cells that are highly migratory, thereby facilitating cancer invasion and metastasis. TGF-β also induces EMT in tumor cells, which can be regulated by oncogenic and anti-oncogenic signals. In addition to EMT promotion, invasion and metastasis of cancer are facilitated by TGF-β through other mechanisms, such as regulation of cell survival, angiogenesis, and vascular integrity, and interaction with the tumor microenvironment. TGF-β also plays a critical role in regulating the cancer-initiating properties of certain types of cells, including glioma-initiating cells. These findings thus may be useful for establishing treatment strategies for advanced cancer by inhibiting TGF-β signaling. Informa Healthcare 2012-05 2012-04-19 /pmc/articles/PMC3339546/ /pubmed/22111550 http://dx.doi.org/10.3109/03009734.2011.638729 Text en © Informa Healthcare http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited. |
spellingShingle | Review Article Miyazono, Kohei Ehata, Shogo Koinuma, Daizo Tumor-promoting functions of transforming growth factor-β in progression of cancer |
title | Tumor-promoting functions of transforming growth factor-β in progression of cancer |
title_full | Tumor-promoting functions of transforming growth factor-β in progression of cancer |
title_fullStr | Tumor-promoting functions of transforming growth factor-β in progression of cancer |
title_full_unstemmed | Tumor-promoting functions of transforming growth factor-β in progression of cancer |
title_short | Tumor-promoting functions of transforming growth factor-β in progression of cancer |
title_sort | tumor-promoting functions of transforming growth factor-β in progression of cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339546/ https://www.ncbi.nlm.nih.gov/pubmed/22111550 http://dx.doi.org/10.3109/03009734.2011.638729 |
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