Fibroblasts—a key host cell type in tumor initiation, progression, and metastasis

Tumor initiation, growth, invasion, and metastasis occur as a consequence of a complex interplay between the host environment and cancer cells. Fibroblasts are now recognized as a key host cell type involved in host–cancer signaling. This review discusses some recent studies that highlight the roles...

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Detalles Bibliográficos
Autores principales: Strell, Carina, Rundqvist, Helene, Östman, Arne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339550/
https://www.ncbi.nlm.nih.gov/pubmed/22509805
http://dx.doi.org/10.3109/03009734.2012.654859
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author Strell, Carina
Rundqvist, Helene
Östman, Arne
author_facet Strell, Carina
Rundqvist, Helene
Östman, Arne
author_sort Strell, Carina
collection PubMed
description Tumor initiation, growth, invasion, and metastasis occur as a consequence of a complex interplay between the host environment and cancer cells. Fibroblasts are now recognized as a key host cell type involved in host–cancer signaling. This review discusses some recent studies that highlight the roles of fibroblasts in tumor initiation, early progression, invasion, and metastasis. Some clinical studies describing the prognostic significance of fibroblast-derived markers and signatures are also discussed.
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spelling pubmed-33395502012-05-24 Fibroblasts—a key host cell type in tumor initiation, progression, and metastasis Strell, Carina Rundqvist, Helene Östman, Arne Ups J Med Sci Review Article Tumor initiation, growth, invasion, and metastasis occur as a consequence of a complex interplay between the host environment and cancer cells. Fibroblasts are now recognized as a key host cell type involved in host–cancer signaling. This review discusses some recent studies that highlight the roles of fibroblasts in tumor initiation, early progression, invasion, and metastasis. Some clinical studies describing the prognostic significance of fibroblast-derived markers and signatures are also discussed. Informa Healthcare 2012-05 2012-04-19 /pmc/articles/PMC3339550/ /pubmed/22509805 http://dx.doi.org/10.3109/03009734.2012.654859 Text en © Informa Healthcare http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Review Article
Strell, Carina
Rundqvist, Helene
Östman, Arne
Fibroblasts—a key host cell type in tumor initiation, progression, and metastasis
title Fibroblasts—a key host cell type in tumor initiation, progression, and metastasis
title_full Fibroblasts—a key host cell type in tumor initiation, progression, and metastasis
title_fullStr Fibroblasts—a key host cell type in tumor initiation, progression, and metastasis
title_full_unstemmed Fibroblasts—a key host cell type in tumor initiation, progression, and metastasis
title_short Fibroblasts—a key host cell type in tumor initiation, progression, and metastasis
title_sort fibroblasts—a key host cell type in tumor initiation, progression, and metastasis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339550/
https://www.ncbi.nlm.nih.gov/pubmed/22509805
http://dx.doi.org/10.3109/03009734.2012.654859
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AT rundqvisthelene fibroblastsakeyhostcelltypeintumorinitiationprogressionandmetastasis
AT ostmanarne fibroblastsakeyhostcelltypeintumorinitiationprogressionandmetastasis

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