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Lacrimal gland lymphoma: Role of radiation therapy

BACKGROUND: To report the clinical and treatment outcome of patients with lacrimal gland lymphoma (LGL) treated with radiation therapy (RT) at Fox Chase Cancer Center, Philadelphia, PA, USA. MATERIALS AND METHODS: Institutional review board approved retrospective chart review of eight patients and l...

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Autores principales: Townsend, Natasha, Turaka, Aruna, Smith, Mitchell R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339673/
https://www.ncbi.nlm.nih.gov/pubmed/22557875
http://dx.doi.org/10.4103/0974-620X.94765
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author Townsend, Natasha
Turaka, Aruna
Smith, Mitchell R.
author_facet Townsend, Natasha
Turaka, Aruna
Smith, Mitchell R.
author_sort Townsend, Natasha
collection PubMed
description BACKGROUND: To report the clinical and treatment outcome of patients with lacrimal gland lymphoma (LGL) treated with radiation therapy (RT) at Fox Chase Cancer Center, Philadelphia, PA, USA. MATERIALS AND METHODS: Institutional review board approved retrospective chart review of eight patients and literature review. RESULTS: The study patients included six males and two females with a mean age of 70 years (range 58-88 years). The mean follow-up period was 23 months (range 3–74 months). Four patients had mucosa-associated lymphoid tissue (50%) lymphoma and four patients had other non-Hodgkin's lymphoma variants. Four patients had bilateral disease (50%). Four patients had primary LGL (stages I-IIAE, 50%) and four had LGL as part of systemic lymphoma (stage IVAE, 50%). The median RT dose was 2987 cGy (range 2880–3015 cGy). All patients had complete response to RT with symptomatic relief. Minimal dry eye was seen in all patients. There were no late effects such as corneal ulcer, radiation retinopathy, maculopathy, papillopathy, or secondary neovascular glaucoma. CONCLUSIONS: RT alone is an extremely effective treatment in the curative management of localized LGL and provides durable, local control of secondary LGL.
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spelling pubmed-33396732012-05-03 Lacrimal gland lymphoma: Role of radiation therapy Townsend, Natasha Turaka, Aruna Smith, Mitchell R. Oman J Ophthalmol Original Article BACKGROUND: To report the clinical and treatment outcome of patients with lacrimal gland lymphoma (LGL) treated with radiation therapy (RT) at Fox Chase Cancer Center, Philadelphia, PA, USA. MATERIALS AND METHODS: Institutional review board approved retrospective chart review of eight patients and literature review. RESULTS: The study patients included six males and two females with a mean age of 70 years (range 58-88 years). The mean follow-up period was 23 months (range 3–74 months). Four patients had mucosa-associated lymphoid tissue (50%) lymphoma and four patients had other non-Hodgkin's lymphoma variants. Four patients had bilateral disease (50%). Four patients had primary LGL (stages I-IIAE, 50%) and four had LGL as part of systemic lymphoma (stage IVAE, 50%). The median RT dose was 2987 cGy (range 2880–3015 cGy). All patients had complete response to RT with symptomatic relief. Minimal dry eye was seen in all patients. There were no late effects such as corneal ulcer, radiation retinopathy, maculopathy, papillopathy, or secondary neovascular glaucoma. CONCLUSIONS: RT alone is an extremely effective treatment in the curative management of localized LGL and provides durable, local control of secondary LGL. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3339673/ /pubmed/22557875 http://dx.doi.org/10.4103/0974-620X.94765 Text en Copyright: © 2012 Townsend N, et al http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Townsend, Natasha
Turaka, Aruna
Smith, Mitchell R.
Lacrimal gland lymphoma: Role of radiation therapy
title Lacrimal gland lymphoma: Role of radiation therapy
title_full Lacrimal gland lymphoma: Role of radiation therapy
title_fullStr Lacrimal gland lymphoma: Role of radiation therapy
title_full_unstemmed Lacrimal gland lymphoma: Role of radiation therapy
title_short Lacrimal gland lymphoma: Role of radiation therapy
title_sort lacrimal gland lymphoma: role of radiation therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339673/
https://www.ncbi.nlm.nih.gov/pubmed/22557875
http://dx.doi.org/10.4103/0974-620X.94765
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