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Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice

The site-specific recombinases Cre and Flp can mutate genes in a spatially and temporally restricted manner in mice. Conditional recombination of the tumor suppressor gene p53 using the Cre-loxP system has led to the development of multiple genetically engineered mouse models of human cancer. Howeve...

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Detalles Bibliográficos
Autores principales:	Lee, Chang-Lung, Moding, Everett J., Huang, Xiaofang, Li, Yifan, Woodlief, Loretta Z., Rodrigues, Rafaela C., Ma, Yan, Kirsch, David G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Limited 2012
Materias:	Resource Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339833/ https://www.ncbi.nlm.nih.gov/pubmed/22228755 http://dx.doi.org/10.1242/dmm.009084

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