Transient Phenomena in Gene Expression after Induction of Transcription

When transcription of a gene is induced by a stimulus, the number of its mRNA molecules changes with time. Here we discuss how this time evolution depends on the shape of the mRNA lifetime distribution. Analysis of the statistical properties of this change reveals transient effects on polysomes, rib...

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Detalles Bibliográficos
Autores principales: Deneke, Carlus, Rudorf, Sophia, Valleriani, Angelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339862/
https://www.ncbi.nlm.nih.gov/pubmed/22558114
http://dx.doi.org/10.1371/journal.pone.0035044
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author Deneke, Carlus
Rudorf, Sophia
Valleriani, Angelo
author_facet Deneke, Carlus
Rudorf, Sophia
Valleriani, Angelo
author_sort Deneke, Carlus
collection PubMed
description When transcription of a gene is induced by a stimulus, the number of its mRNA molecules changes with time. Here we discuss how this time evolution depends on the shape of the mRNA lifetime distribution. Analysis of the statistical properties of this change reveals transient effects on polysomes, ribosomal profiles, and rate of protein synthesis. Our studies reveal that transient phenomena in gene expression strongly depend on the specific form of the mRNA lifetime distribution.
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spelling pubmed-33398622012-05-03 Transient Phenomena in Gene Expression after Induction of Transcription Deneke, Carlus Rudorf, Sophia Valleriani, Angelo PLoS One Research Article When transcription of a gene is induced by a stimulus, the number of its mRNA molecules changes with time. Here we discuss how this time evolution depends on the shape of the mRNA lifetime distribution. Analysis of the statistical properties of this change reveals transient effects on polysomes, ribosomal profiles, and rate of protein synthesis. Our studies reveal that transient phenomena in gene expression strongly depend on the specific form of the mRNA lifetime distribution. Public Library of Science 2012-04-23 /pmc/articles/PMC3339862/ /pubmed/22558114 http://dx.doi.org/10.1371/journal.pone.0035044 Text en Deneke et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Deneke, Carlus
Rudorf, Sophia
Valleriani, Angelo
Transient Phenomena in Gene Expression after Induction of Transcription
title Transient Phenomena in Gene Expression after Induction of Transcription
title_full Transient Phenomena in Gene Expression after Induction of Transcription
title_fullStr Transient Phenomena in Gene Expression after Induction of Transcription
title_full_unstemmed Transient Phenomena in Gene Expression after Induction of Transcription
title_short Transient Phenomena in Gene Expression after Induction of Transcription
title_sort transient phenomena in gene expression after induction of transcription
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339862/
https://www.ncbi.nlm.nih.gov/pubmed/22558114
http://dx.doi.org/10.1371/journal.pone.0035044
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