Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist

BACKGROUND: The pathologic diagnosis of isolated myocarditis without pericardial involvement is uncommonly encountered in systemic onset Juvenile Idiopathic Arthritis (soJIA). CASE: An eleven year-old boy with soJIA died suddenly while being treated with the interleukin 1 (IL-1) receptor inhibitor,...

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Detalles Bibliográficos
Autores principales: Zeft, Andrew S, Menon, Shaji C, Miller, Dylan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340295/
https://www.ncbi.nlm.nih.gov/pubmed/22490470
http://dx.doi.org/10.1186/1546-0096-10-8
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author Zeft, Andrew S
Menon, Shaji C
Miller, Dylan
author_facet Zeft, Andrew S
Menon, Shaji C
Miller, Dylan
author_sort Zeft, Andrew S
collection PubMed
description BACKGROUND: The pathologic diagnosis of isolated myocarditis without pericardial involvement is uncommonly encountered in systemic onset Juvenile Idiopathic Arthritis (soJIA). CASE: An eleven year-old boy with soJIA died suddenly while being treated with the interleukin 1 (IL-1) receptor inhibitor, anakinra. His autopsy revealed an enlarged heart and microscopic findings were consistent with myocarditis, but not pericarditis. Viral PCR testing performed on his myocardial tissue was negative. CONCLUSION: This case illustrates myocarditis as a fatal complication of soJIA, potentially enabled by anakinra.
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spelling pubmed-33402952012-05-01 Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist Zeft, Andrew S Menon, Shaji C Miller, Dylan Pediatr Rheumatol Online J Case Report BACKGROUND: The pathologic diagnosis of isolated myocarditis without pericardial involvement is uncommonly encountered in systemic onset Juvenile Idiopathic Arthritis (soJIA). CASE: An eleven year-old boy with soJIA died suddenly while being treated with the interleukin 1 (IL-1) receptor inhibitor, anakinra. His autopsy revealed an enlarged heart and microscopic findings were consistent with myocarditis, but not pericarditis. Viral PCR testing performed on his myocardial tissue was negative. CONCLUSION: This case illustrates myocarditis as a fatal complication of soJIA, potentially enabled by anakinra. BioMed Central 2012-04-10 /pmc/articles/PMC3340295/ /pubmed/22490470 http://dx.doi.org/10.1186/1546-0096-10-8 Text en Copyright ©2012 Zeft et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Zeft, Andrew S
Menon, Shaji C
Miller, Dylan
Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist
title Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist
title_full Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist
title_fullStr Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist
title_full_unstemmed Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist
title_short Fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist
title_sort fatal myocarditis in a child with systemic onset juvenile idiopathic arthritis during treatment with an interleukin 1 receptor antagonist
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340295/
https://www.ncbi.nlm.nih.gov/pubmed/22490470
http://dx.doi.org/10.1186/1546-0096-10-8
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