Amyloid-Beta (Aβ) D7H Mutation Increases Oligomeric Aβ42 and Alters Properties of Aβ-Zinc/Copper Assemblies

Amyloid precursor protein (APP) mutations associated with familial Alzheimer's disease (AD) usually lead to increases in amyloid β-protein (Aβ) levels or aggregation. Here, we identified a novel APP mutation, located within the Aβ sequence (Aβ(D7H)), in a Taiwanese family with early onset AD an...

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Detalles Bibliográficos
Autores principales: Chen, Wei-Ting, Hong, Chen-Jee, Lin, Ya-Tzu, Chang, Wen-Han, Huang, He-Ting, Liao, Jhih-Ying, Chang, Yu-Jen, Hsieh, Yi-Fang, Cheng, Chih-Ya, Liu, Hsiu-Chih, Chen, Yun-Ru, Cheng, Irene H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340413/
https://www.ncbi.nlm.nih.gov/pubmed/22558227
http://dx.doi.org/10.1371/journal.pone.0035807

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