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Finding a niche: studies from the Drosophila ovary

Specialized microenvironments called niches help maintain stem cells in an undifferentiated and self-renewing state. The existence of niches has long been predicted from mammalian studies, but identifying stem cells in their native environments in vivo has remained a challenge in most vertebrates. M...

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Detalles Bibliográficos
Autores principales: Eliazer, Susan, Buszczak, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340554/
https://www.ncbi.nlm.nih.gov/pubmed/22117545
http://dx.doi.org/10.1186/scrt86
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author Eliazer, Susan
Buszczak, Michael
author_facet Eliazer, Susan
Buszczak, Michael
author_sort Eliazer, Susan
collection PubMed
description Specialized microenvironments called niches help maintain stem cells in an undifferentiated and self-renewing state. The existence of niches has long been predicted from mammalian studies, but identifying stem cells in their native environments in vivo has remained a challenge in most vertebrates. Many of the mechanistic insights into how niches regulate stem cell maintenance have been obtained using invertebrate models such as Drosophila. Here, we focus on the Drosophila ovarian germline stem cell niche and review recent studies that have begun to reveal how intricate crosstalk between various signaling pathways regulates stem cell maintenance, how the extracellular matrix modulates the signaling output of the niche and how epigenetic programming influences cell development and function both inside and outside the niche to ensure proper tissue homeostasis. These insights will probably inform the study of mammalian niches and how their malfunction contributes to human disease.
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spelling pubmed-33405542012-05-01 Finding a niche: studies from the Drosophila ovary Eliazer, Susan Buszczak, Michael Stem Cell Res Ther Review Specialized microenvironments called niches help maintain stem cells in an undifferentiated and self-renewing state. The existence of niches has long been predicted from mammalian studies, but identifying stem cells in their native environments in vivo has remained a challenge in most vertebrates. Many of the mechanistic insights into how niches regulate stem cell maintenance have been obtained using invertebrate models such as Drosophila. Here, we focus on the Drosophila ovarian germline stem cell niche and review recent studies that have begun to reveal how intricate crosstalk between various signaling pathways regulates stem cell maintenance, how the extracellular matrix modulates the signaling output of the niche and how epigenetic programming influences cell development and function both inside and outside the niche to ensure proper tissue homeostasis. These insights will probably inform the study of mammalian niches and how their malfunction contributes to human disease. BioMed Central 2011-11-25 /pmc/articles/PMC3340554/ /pubmed/22117545 http://dx.doi.org/10.1186/scrt86 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Review
Eliazer, Susan
Buszczak, Michael
Finding a niche: studies from the Drosophila ovary
title Finding a niche: studies from the Drosophila ovary
title_full Finding a niche: studies from the Drosophila ovary
title_fullStr Finding a niche: studies from the Drosophila ovary
title_full_unstemmed Finding a niche: studies from the Drosophila ovary
title_short Finding a niche: studies from the Drosophila ovary
title_sort finding a niche: studies from the drosophila ovary
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340554/
https://www.ncbi.nlm.nih.gov/pubmed/22117545
http://dx.doi.org/10.1186/scrt86
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