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Changing the Waveform of Circadian Rhythms: Considerations for Shift-Work
Circadian disruption in shift-work is common and has deleterious effects on health and performance. Current efforts to mitigate these harms reasonably focus on the phase of the circadian pacemaker, which unfortunately in humans, shifts slowly and often incompletely. Temporal reorganization of rhythm...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340571/ https://www.ncbi.nlm.nih.gov/pubmed/22557994 http://dx.doi.org/10.3389/fneur.2012.00072 |
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author | Harrison, Elizabeth M. Gorman, Michael R. |
author_facet | Harrison, Elizabeth M. Gorman, Michael R. |
author_sort | Harrison, Elizabeth M. |
collection | PubMed |
description | Circadian disruption in shift-work is common and has deleterious effects on health and performance. Current efforts to mitigate these harms reasonably focus on the phase of the circadian pacemaker, which unfortunately in humans, shifts slowly and often incompletely. Temporal reorganization of rhythmic waveform (i.e., the shape of its 24 h oscillation), rather than phase, however, may better match performance demands of shift-workers and can be quickly and feasibly implemented in animals. In fact, a bifurcated pacemaker waveform may permit stable entrainment of a bimodal sleep/wake rhythm promoting alertness in both night and daylight hours. Although bifurcation has yet to be formally assessed in humans, evidence of conserved properties of circadian organization and plasticity predict its occurrence: humans respond to conventional manipulations of waveform (e.g., photoperiodism); behaviorally, the sleep/wake rhythm is adaptable; and finally, the human circadian system likely derives from the same multiple cellular oscillators that permit waveform flexibility in the rodent pacemaker. In short, investigation into untried manipulations of waveform in humans to facilitate adjustment to challenging schedules is justified. |
format | Online Article Text |
id | pubmed-3340571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33405712012-05-03 Changing the Waveform of Circadian Rhythms: Considerations for Shift-Work Harrison, Elizabeth M. Gorman, Michael R. Front Neurol Neurology Circadian disruption in shift-work is common and has deleterious effects on health and performance. Current efforts to mitigate these harms reasonably focus on the phase of the circadian pacemaker, which unfortunately in humans, shifts slowly and often incompletely. Temporal reorganization of rhythmic waveform (i.e., the shape of its 24 h oscillation), rather than phase, however, may better match performance demands of shift-workers and can be quickly and feasibly implemented in animals. In fact, a bifurcated pacemaker waveform may permit stable entrainment of a bimodal sleep/wake rhythm promoting alertness in both night and daylight hours. Although bifurcation has yet to be formally assessed in humans, evidence of conserved properties of circadian organization and plasticity predict its occurrence: humans respond to conventional manipulations of waveform (e.g., photoperiodism); behaviorally, the sleep/wake rhythm is adaptable; and finally, the human circadian system likely derives from the same multiple cellular oscillators that permit waveform flexibility in the rodent pacemaker. In short, investigation into untried manipulations of waveform in humans to facilitate adjustment to challenging schedules is justified. Frontiers Research Foundation 2012-05-01 /pmc/articles/PMC3340571/ /pubmed/22557994 http://dx.doi.org/10.3389/fneur.2012.00072 Text en Copyright © 2012 Harrison and Gorman. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Neurology Harrison, Elizabeth M. Gorman, Michael R. Changing the Waveform of Circadian Rhythms: Considerations for Shift-Work |
title | Changing the Waveform of Circadian Rhythms: Considerations for Shift-Work |
title_full | Changing the Waveform of Circadian Rhythms: Considerations for Shift-Work |
title_fullStr | Changing the Waveform of Circadian Rhythms: Considerations for Shift-Work |
title_full_unstemmed | Changing the Waveform of Circadian Rhythms: Considerations for Shift-Work |
title_short | Changing the Waveform of Circadian Rhythms: Considerations for Shift-Work |
title_sort | changing the waveform of circadian rhythms: considerations for shift-work |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340571/ https://www.ncbi.nlm.nih.gov/pubmed/22557994 http://dx.doi.org/10.3389/fneur.2012.00072 |
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