Methotrexate Induced Lung Injury in a Patient with Primary CNS Lymphoma: a Case Report

Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal e...

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Autores principales: Chhabra, Puneet, Law, Arjun Dutt, Suri, Vikas, Malhotra, Pankaj, Varma, Subhash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2012
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340991/
https://www.ncbi.nlm.nih.gov/pubmed/22550565
http://dx.doi.org/10.4084/MJHID.2012.020
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author Chhabra, Puneet
Law, Arjun Dutt
Suri, Vikas
Malhotra, Pankaj
Varma, Subhash
author_facet Chhabra, Puneet
Law, Arjun Dutt
Suri, Vikas
Malhotra, Pankaj
Varma, Subhash
author_sort Chhabra, Puneet
collection PubMed
description Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate. Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate.
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spelling pubmed-33409912012-05-01 Methotrexate Induced Lung Injury in a Patient with Primary CNS Lymphoma: a Case Report Chhabra, Puneet Law, Arjun Dutt Suri, Vikas Malhotra, Pankaj Varma, Subhash Mediterr J Hematol Infect Dis Case Reports Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate. Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate. Università Cattolica del Sacro Cuore 2012-04-02 /pmc/articles/PMC3340991/ /pubmed/22550565 http://dx.doi.org/10.4084/MJHID.2012.020 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Chhabra, Puneet
Law, Arjun Dutt
Suri, Vikas
Malhotra, Pankaj
Varma, Subhash
Methotrexate Induced Lung Injury in a Patient with Primary CNS Lymphoma: a Case Report
title Methotrexate Induced Lung Injury in a Patient with Primary CNS Lymphoma: a Case Report
title_full Methotrexate Induced Lung Injury in a Patient with Primary CNS Lymphoma: a Case Report
title_fullStr Methotrexate Induced Lung Injury in a Patient with Primary CNS Lymphoma: a Case Report
title_full_unstemmed Methotrexate Induced Lung Injury in a Patient with Primary CNS Lymphoma: a Case Report
title_short Methotrexate Induced Lung Injury in a Patient with Primary CNS Lymphoma: a Case Report
title_sort methotrexate induced lung injury in a patient with primary cns lymphoma: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340991/
https://www.ncbi.nlm.nih.gov/pubmed/22550565
http://dx.doi.org/10.4084/MJHID.2012.020
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AT malhotrapankaj methotrexateinducedlunginjuryinapatientwithprimarycnslymphomaacasereport
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