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An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component
Intrinsically disordered proteins play causative roles in many human diseases. Their overexpression is toxic in many organisms, but the causes of toxicity are opaque. In this paper, we exploit yeast technologies to determine the root of toxicity for one such protein, the yeast prion Rnq1. This prote...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341155/ https://www.ncbi.nlm.nih.gov/pubmed/22529103 http://dx.doi.org/10.1083/jcb.201108146 |