Cargando…

Oncolytic Effects of a Novel Influenza A Virus Expressing Interleukin-15 from the NS Reading Frame

Oncolytic influenza A viruses with deleted NS1 gene (delNS1) replicate selectively in tumour cells with defective interferon response and/or activated Ras/Raf/MEK/ERK signalling pathway. To develop a delNS1 virus with specific immunostimulatory properties, we used an optimised technology to insert t...

Descripción completa

Detalles Bibliográficos
Autores principales:	van Rikxoort, Marijke, Michaelis, Martin, Wolschek, Markus, Muster, Thomas, Egorov, Andrej, Seipelt, Joachim, Doerr, Hans Wilhelm, Cinatl, Jindrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341362/ https://www.ncbi.nlm.nih.gov/pubmed/22563505 http://dx.doi.org/10.1371/journal.pone.0036506

Ejemplares similares

Investigation of the influence of EPs(®) 7630, a herbal drug preparation from Pelargonium sidoides, on replication of a broad panel of respiratory viruses
por: Michaelis, Martin, et al.
Publicado: (2011)

Association between acquired resistance to PLX4032 (vemurafenib) and ATP-binding cassette transporter expression
por: Michaelis, Martin, et al.
Publicado: (2014)

Single HA2 Mutation Increases the Infectivity and Immunogenicity of a Live Attenuated H5N1 Intranasal Influenza Vaccine Candidate Lacking NS1
por: Krenn, Brigitte M., et al.
Publicado: (2011)

Development of antiviral therapy for severe acute respiratory syndrome
por: Cinatl, Jindrich, et al.
Publicado: (2005)

Inhibition of apoptosis prevents West Nile virus induced cell death
por: Kleinschmidt, Malte C, et al.
Publicado: (2007)

Glycyrrhizin Exerts Antioxidative Effects in H5N1 Influenza A Virus-Infected Cells and Inhibits Virus Replication and Pro-Inflammatory Gene Expression
por: Michaelis, Martin, et al.
Publicado: (2011)

Ribavirin and interferon-β synergistically inhibit SARS-associated coronavirus replication in animal and human cell lines
por: Morgenstern, Birgit, et al.
Publicado: (2005)

Exosomal vaccines containing the S protein of the SARS coronavirus induce high levels of neutralizing antibodies
por: Kuate, Seraphin, et al.
Publicado: (2007)

Influenza virus vector iNS1 expressing bovine papillomavirus 1 (BPV1) antigens efficiently induces tumour regression in equine sarcoid patients
por: Jindra, Christoph, et al.
Publicado: (2021)

Glycyrrhizin inhibits highly pathogenic H5N1 influenza A virus-induced pro-inflammatory cytokine and chemokine expression in human macrophages
por: Michaelis, Martin, et al.
Publicado: (2010)

Preclinical Evaluation of a Replication-Deficient Intranasal ΔNS1 H5N1 Influenza Vaccine
por: Romanova, Julia, et al.
Publicado: (2009)

Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells
por: Michaelis, Martin, et al.
Publicado: (2009)

Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication
por: Chen, Chung-Jen, et al.
Publicado: (2008)

uORF4u: a tool for annotation of conserved upstream open reading frames
por: Egorov, Artyom A, et al.
Publicado: (2023)

Effects of flavonoid-induced oxidative stress on anti-H5N1 influenza a virus activity exerted by baicalein and biochanin A
por: Michaelis, Martin, et al.
Publicado: (2014)

Drug-adapted cancer cell lines as preclinical models of acquired resistance
por: Michaelis, Martin, et al.
Publicado: (2019)

Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells
por: Michaelis, M, et al.
Publicado: (2011)

Production of Bioactive Soluble Interleukin-15 in Complex with Interleukin-15 Receptor Alpha from a Conditionally-Replicating Oncolytic HSV-1
por: Gaston, David C., et al.
Publicado: (2013)

Chemoresistance induces enhanced adhesion and transendothelial penetration of neuroblastoma cells by down-regulating NCAM surface expression
por: Blaheta, Roman A, et al.
Publicado: (2006)

ABCG2 impairs the activity of the aurora kinase inhibitor tozasertib but not of alisertib
por: Michaelis, Martin, et al.
Publicado: (2015)

Aurora Kinases as Targets in Drug-Resistant Neuroblastoma Cells
por: Michaelis, Martin, et al.
Publicado: (2014)

Oncolytic therapy with recombinant vaccinia viruses targeting the interleukin-15 pathway elicits a synergistic response
por: Shakiba, Yasmin, et al.
Publicado: (2023)

Selection Pressure in Alternative Reading Frames
por: Mir, Katharina, et al.
Publicado: (2014)

Recognition of correct reading frame by the ribosome
por: Trifonov, E.N.
Publicado: (1992)

How ‘hidden’ reading frames are expressed
por: Cattaneo, Roberto
Publicado: (1989)

Enzastaurin inhibits ABCB1-mediated drug efflux independently of effects on protein kinase C signalling and the cellular p53 status
por: Michaelis, Martin, et al.
Publicado: (2015)

Non-Phosphorylatable PEA-15 Sensitises SKOV-3 Ovarian Cancer Cells to Cisplatin
por: Dilruba, Shahana, et al.
Publicado: (2020)

Targeting an Oncolytic Influenza A Virus to Tumor Tissue by Elastase
por: Kuznetsova, Irina, et al.
Publicado: (2017)

SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment
por: Bojkova, Denisa, et al.
Publicado: (2022)

Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates
por: Bojkova, Denisa, et al.
Publicado: (2022)

Open Reading Frame Phylogenetic Analysis on the Cloud
por: Hung, Che-Lun, et al.
Publicado: (2013)

Noise reduction by upstream open reading frames
por: Wu, Ho-Wei, et al.
Publicado: (2022)

Oncolytic virotherapy targeting the IL15 pathway
por: Yoo, So Young, et al.
Publicado: (2023)

Human neuroblastoma cells with acquired resistance to the p53 activator RITA retain functional p53 and sensitivity to other p53 activating agents
por: Michaelis, M, et al.
Publicado: (2012)

ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance
por: Löschmann, Nadine, et al.
Publicado: (2016)

Incorporation of doxorubicin in different polymer nanoparticles and their anticancer activity
por: Pieper, Sebastian, et al.
Publicado: (2019)

Selection of a highly invasive neuroblastoma cell population through long-term human cytomegalovirus infection
por: Michaelis, M, et al.
Publicado: (2012)

Intranasal Immunization with the Influenza A Virus Encoding Truncated NS1 Protein Protects Mice from Heterologous Challenge by Restraining the Inflammatory Response in the Lungs
por: Vasilyev, Kirill, et al.
Publicado: (2021)

HAltORF: a database of predicted out-of-frame alternative open reading frames in human
por: Vanderperre, Benoît, et al.
Publicado: (2012)

Conserved upstream open reading frames in higher plants
por: Tran, Michael K, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_locb3lqu4nmk1oomau1itdsna2