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Is Myocardial Infarction in Patients without Significant Stenosis on a Coronary Angiogram as Benign as Believed?
The present study aimed to investigate the clinical characteristics and 1-year outcomes of acute myocardial infarction (AMI) patients without significant stenosis on a coronary angiogram comparison with the clinical characteristics and outcomes of patients with significant coronary artery stenosis....
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chonnam National University Medical School
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341436/ https://www.ncbi.nlm.nih.gov/pubmed/22570814 http://dx.doi.org/10.4068/cmj.2012.48.1.39 |
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author | Rhew, Shi Hyun Ahn, Youngkeun Kim, Min Chul Jang, Su Young Cho, Kyung Hoon Hwang, Seung Hwan Lee, Min Goo Ko, Jum Suk Park, Keun Ho Sim, Doo Sun Yoon, Nam Sik Yoon, Hyun Ju Kim, Kye Hun Hong, Young Joon Park, Hyung Wook Kim, Ju Han Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee |
author_facet | Rhew, Shi Hyun Ahn, Youngkeun Kim, Min Chul Jang, Su Young Cho, Kyung Hoon Hwang, Seung Hwan Lee, Min Goo Ko, Jum Suk Park, Keun Ho Sim, Doo Sun Yoon, Nam Sik Yoon, Hyun Ju Kim, Kye Hun Hong, Young Joon Park, Hyung Wook Kim, Ju Han Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee |
author_sort | Rhew, Shi Hyun |
collection | PubMed |
description | The present study aimed to investigate the clinical characteristics and 1-year outcomes of acute myocardial infarction (AMI) patients without significant stenosis on a coronary angiogram comparison with the clinical characteristics and outcomes of patients with significant coronary artery stenosis. A total of 1,220 patients with AMI were retrospectively classified into Group I (≥50% diameter stenosis, n=1,120) and Group II (<50%, n=100). Group II was further divided into two subgroups according to the underlying etiology: cryptogenic (Group II-a, n=54) and those with possible causative factors (Group II-b, n=46). Patients in Group II were younger, were more likely to be women, and were less likely to smoke and to have diabetes mellitus than were patients in Group I. The levels of cardiac enzymes, LDL-cholesterol levels, and the apo-B/A1 ratio were lower in Group II. However, 1-month and 12-month rates of major adverse cardiac events (MACE) were not significantly different between the two groups. The Group II-b subgroup comprised 29 patients with vasospasm, 11 with myocardial bridge, and 6 with spontaneous thrombolysis. Left ventricular ejection fraction and creatinine clearance were lower and levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) were higher in Group II-a than in Group II-b. However, outcomes including MACE and mortality at 12 months were not significantly different between the two subgroups. The 1-year outcomes of patients in Group II were similar to those of patients in Group I. The clinical outcomes in Group II-a were also similar to those of Group II-b, although the former group showed higher levels of NT-proBNP and hs-CRP. |
format | Online Article Text |
id | pubmed-3341436 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Chonnam National University Medical School |
record_format | MEDLINE/PubMed |
spelling | pubmed-33414362012-05-08 Is Myocardial Infarction in Patients without Significant Stenosis on a Coronary Angiogram as Benign as Believed? Rhew, Shi Hyun Ahn, Youngkeun Kim, Min Chul Jang, Su Young Cho, Kyung Hoon Hwang, Seung Hwan Lee, Min Goo Ko, Jum Suk Park, Keun Ho Sim, Doo Sun Yoon, Nam Sik Yoon, Hyun Ju Kim, Kye Hun Hong, Young Joon Park, Hyung Wook Kim, Ju Han Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee Chonnam Med J Original Article The present study aimed to investigate the clinical characteristics and 1-year outcomes of acute myocardial infarction (AMI) patients without significant stenosis on a coronary angiogram comparison with the clinical characteristics and outcomes of patients with significant coronary artery stenosis. A total of 1,220 patients with AMI were retrospectively classified into Group I (≥50% diameter stenosis, n=1,120) and Group II (<50%, n=100). Group II was further divided into two subgroups according to the underlying etiology: cryptogenic (Group II-a, n=54) and those with possible causative factors (Group II-b, n=46). Patients in Group II were younger, were more likely to be women, and were less likely to smoke and to have diabetes mellitus than were patients in Group I. The levels of cardiac enzymes, LDL-cholesterol levels, and the apo-B/A1 ratio were lower in Group II. However, 1-month and 12-month rates of major adverse cardiac events (MACE) were not significantly different between the two groups. The Group II-b subgroup comprised 29 patients with vasospasm, 11 with myocardial bridge, and 6 with spontaneous thrombolysis. Left ventricular ejection fraction and creatinine clearance were lower and levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) were higher in Group II-a than in Group II-b. However, outcomes including MACE and mortality at 12 months were not significantly different between the two subgroups. The 1-year outcomes of patients in Group II were similar to those of patients in Group I. The clinical outcomes in Group II-a were also similar to those of Group II-b, although the former group showed higher levels of NT-proBNP and hs-CRP. Chonnam National University Medical School 2012-04 2012-04-26 /pmc/articles/PMC3341436/ /pubmed/22570814 http://dx.doi.org/10.4068/cmj.2012.48.1.39 Text en © Chonnam Medical Journal, 2012 http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Rhew, Shi Hyun Ahn, Youngkeun Kim, Min Chul Jang, Su Young Cho, Kyung Hoon Hwang, Seung Hwan Lee, Min Goo Ko, Jum Suk Park, Keun Ho Sim, Doo Sun Yoon, Nam Sik Yoon, Hyun Ju Kim, Kye Hun Hong, Young Joon Park, Hyung Wook Kim, Ju Han Jeong, Myung Ho Cho, Jeong Gwan Park, Jong Chun Kang, Jung Chaee Is Myocardial Infarction in Patients without Significant Stenosis on a Coronary Angiogram as Benign as Believed? |
title | Is Myocardial Infarction in Patients without Significant Stenosis on a Coronary Angiogram as Benign as Believed? |
title_full | Is Myocardial Infarction in Patients without Significant Stenosis on a Coronary Angiogram as Benign as Believed? |
title_fullStr | Is Myocardial Infarction in Patients without Significant Stenosis on a Coronary Angiogram as Benign as Believed? |
title_full_unstemmed | Is Myocardial Infarction in Patients without Significant Stenosis on a Coronary Angiogram as Benign as Believed? |
title_short | Is Myocardial Infarction in Patients without Significant Stenosis on a Coronary Angiogram as Benign as Believed? |
title_sort | is myocardial infarction in patients without significant stenosis on a coronary angiogram as benign as believed? |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341436/ https://www.ncbi.nlm.nih.gov/pubmed/22570814 http://dx.doi.org/10.4068/cmj.2012.48.1.39 |
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