Clinical Assessment of PTEN Loss in Endometrial Carcinoma: Immunohistochemistry Out-Performs Gene Sequencing

PTEN is a tumor suppressor that negatively regulates the PI3K-AKT signaling pathway, which is implicated in the pathogenesis of endometrial carcinoma. Sanger sequencing has been considered to be the gold standard for detection of PTEN sequence abnormalities. However, this approach fails to address t...

Descripción completa

Detalles Bibliográficos
Autores principales: Djordjevic, Bojana, Hennessy, Bryan T., Li, Jie, Barkoh, Bedia A., Luthra, Rajyalakshmi, Mills, Gordon B., Broaddus, Russell R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341518/
https://www.ncbi.nlm.nih.gov/pubmed/22301702
http://dx.doi.org/10.1038/modpathol.2011.208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341518/
https://www.ncbi.nlm.nih.gov/pubmed/22301702
http://dx.doi.org/10.1038/modpathol.2011.208

Ejemplares similares