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Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case–control study

OBJECTIVES: The irreversible airflow limitation characterised by chronic obstructive pulmonary disease (COPD) causes a decrease in the oxygen supply to the brain. The aim of the present study was to investigate brain structural damage in COPD. DESIGN: Retrospective case–control study. Patients with...

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Autores principales: Zhang, Haiyan, Wang, Xiaochuan, Lin, Jianzhong, Sun, Yinchuan, Huang, Yongxia, Yang, Tianhe, Zheng, Shili, Fan, Ming, Zhang, Jiaxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341600/
https://www.ncbi.nlm.nih.gov/pubmed/22535793
http://dx.doi.org/10.1136/bmjopen-2012-000844
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author Zhang, Haiyan
Wang, Xiaochuan
Lin, Jianzhong
Sun, Yinchuan
Huang, Yongxia
Yang, Tianhe
Zheng, Shili
Fan, Ming
Zhang, Jiaxing
author_facet Zhang, Haiyan
Wang, Xiaochuan
Lin, Jianzhong
Sun, Yinchuan
Huang, Yongxia
Yang, Tianhe
Zheng, Shili
Fan, Ming
Zhang, Jiaxing
author_sort Zhang, Haiyan
collection PubMed
description OBJECTIVES: The irreversible airflow limitation characterised by chronic obstructive pulmonary disease (COPD) causes a decrease in the oxygen supply to the brain. The aim of the present study was to investigate brain structural damage in COPD. DESIGN: Retrospective case–control study. Patients with COPD and healthy volunteers were recruited. The two groups were matched in age, gender and educational background. SETTING: A hospital and a number of communities: they are all located in southern Fujian province, China. PARTICIPANTS: 25 stable patients and 25 controls were enrolled from December 2009 to May 2011. METHODS: Using voxel-based morphometry and tract-based spatial statistics based on MRI to analyse grey matter (GM) density and white matter fractional anisotropy (FA), respectively, and a battery of neuropsychological tests were performed. RESULTS: Patients with COPD (vs controls) showed decreased GM density in the limbic and paralimbic structures, including right gyrus rectus, left precentral gyrus, bilateral anterior and middle cingulate gyri, bilateral superior temporal gyri, bilateral anterior insula extending to Rolandic operculum, bilateral thalamus/pulvinars and left caudate nucleus. Patients with COPD (vs controls) had decreased FA values in the bilateral superior corona radiata, bilateral superior and inferior longitudinal fasciculus, bilateral optic radiation, bilateral lingual gyri, left parahippocampal gyrus and fornix. Lower FA values in these regions were associated with increased radial diffusivity and no changes of longitudinal diffusivity. Patients with COPD had poor performances in the Mini-Mental State Examination, figure memory and visual reproduction. GM density in some decreased regions in COPD had positive correlations with arterial blood Po(2), negative correlations with disease duration and also positive correlations with visual tasks. CONCLUSION: The authors demonstrated that COPD exhibited loss of regional GM accompanied by impairment of white matter microstructural integrity, which was associated with disease severity and may underlie the pathophysiological and psychological changes of COPD.
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spelling pubmed-33416002012-05-03 Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case–control study Zhang, Haiyan Wang, Xiaochuan Lin, Jianzhong Sun, Yinchuan Huang, Yongxia Yang, Tianhe Zheng, Shili Fan, Ming Zhang, Jiaxing BMJ Open Radiology and Imaging OBJECTIVES: The irreversible airflow limitation characterised by chronic obstructive pulmonary disease (COPD) causes a decrease in the oxygen supply to the brain. The aim of the present study was to investigate brain structural damage in COPD. DESIGN: Retrospective case–control study. Patients with COPD and healthy volunteers were recruited. The two groups were matched in age, gender and educational background. SETTING: A hospital and a number of communities: they are all located in southern Fujian province, China. PARTICIPANTS: 25 stable patients and 25 controls were enrolled from December 2009 to May 2011. METHODS: Using voxel-based morphometry and tract-based spatial statistics based on MRI to analyse grey matter (GM) density and white matter fractional anisotropy (FA), respectively, and a battery of neuropsychological tests were performed. RESULTS: Patients with COPD (vs controls) showed decreased GM density in the limbic and paralimbic structures, including right gyrus rectus, left precentral gyrus, bilateral anterior and middle cingulate gyri, bilateral superior temporal gyri, bilateral anterior insula extending to Rolandic operculum, bilateral thalamus/pulvinars and left caudate nucleus. Patients with COPD (vs controls) had decreased FA values in the bilateral superior corona radiata, bilateral superior and inferior longitudinal fasciculus, bilateral optic radiation, bilateral lingual gyri, left parahippocampal gyrus and fornix. Lower FA values in these regions were associated with increased radial diffusivity and no changes of longitudinal diffusivity. Patients with COPD had poor performances in the Mini-Mental State Examination, figure memory and visual reproduction. GM density in some decreased regions in COPD had positive correlations with arterial blood Po(2), negative correlations with disease duration and also positive correlations with visual tasks. CONCLUSION: The authors demonstrated that COPD exhibited loss of regional GM accompanied by impairment of white matter microstructural integrity, which was associated with disease severity and may underlie the pathophysiological and psychological changes of COPD. BMJ Group 2012-04-24 /pmc/articles/PMC3341600/ /pubmed/22535793 http://dx.doi.org/10.1136/bmjopen-2012-000844 Text en © 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
spellingShingle Radiology and Imaging
Zhang, Haiyan
Wang, Xiaochuan
Lin, Jianzhong
Sun, Yinchuan
Huang, Yongxia
Yang, Tianhe
Zheng, Shili
Fan, Ming
Zhang, Jiaxing
Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case–control study
title Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case–control study
title_full Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case–control study
title_fullStr Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case–control study
title_full_unstemmed Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case–control study
title_short Grey and white matter abnormalities in chronic obstructive pulmonary disease: a case–control study
title_sort grey and white matter abnormalities in chronic obstructive pulmonary disease: a case–control study
topic Radiology and Imaging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341600/
https://www.ncbi.nlm.nih.gov/pubmed/22535793
http://dx.doi.org/10.1136/bmjopen-2012-000844
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