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AA amyloidosis in the renal allograft: a report of two cases and review of the literature

AA amyloidosis is a disorder characterized by the abnormal formation, accumulation and systemic deposition of fibrillary material that frequently involves the kidney. Recurrent AA amyloidosis in the renal allograft has been documented in patients with tuberculosis, familial Mediterranean fever, anky...

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Autores principales: Rojas, Rebecca, Josephson, Michelle A., Chang, Anthony, Meehan, Shane M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341841/
https://www.ncbi.nlm.nih.gov/pubmed/22833808
http://dx.doi.org/10.1093/ckj/sfs019
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author Rojas, Rebecca
Josephson, Michelle A.
Chang, Anthony
Meehan, Shane M.
author_facet Rojas, Rebecca
Josephson, Michelle A.
Chang, Anthony
Meehan, Shane M.
author_sort Rojas, Rebecca
collection PubMed
description AA amyloidosis is a disorder characterized by the abnormal formation, accumulation and systemic deposition of fibrillary material that frequently involves the kidney. Recurrent AA amyloidosis in the renal allograft has been documented in patients with tuberculosis, familial Mediterranean fever, ankylosing spondylitis, chronic pyelonephritis and rheumatoid arthritis. De novo AA amyloidosis is rarely described. We report two cases of AA amyloidosis in the renal allograft. Our first case is a 47-year-old male with a history of ankylosing spondylitis who developed end-stage renal disease reportedly from tubulointerstitial nephritis from non-steroidal anti-inflammatory agent use. A biopsy was never performed. One year after transplantation, AA amyloidosis was identified in the femoral head and 8 years post-transplantation, AA amyloidosis was identified in the renal allograft. He was treated with colchicine and adalimumab and has stable renal function at 1 year-follow-up. Our second case is a 57-year-old male with a long history of intravenous drug use and hepatitis C infection who developed end-stage kidney disease due to AA amyloidosis. Our second patient's course was complicated by renal adenovirus, pulmonary aspergillosis and hepatitis C with AA amyloidosis subsequently being identified in the allograft 2.5 years post-transplantation. Renal allograft function remains stable 4-years post-transplantation. These reports describe clinical and pathologic features of two cases of AA amyloidosis presenting with proteinuria and focal involvement of the renal allograft.
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spelling pubmed-33418412012-08-28 AA amyloidosis in the renal allograft: a report of two cases and review of the literature Rojas, Rebecca Josephson, Michelle A. Chang, Anthony Meehan, Shane M. Clin Kidney J Original Contributions AA amyloidosis is a disorder characterized by the abnormal formation, accumulation and systemic deposition of fibrillary material that frequently involves the kidney. Recurrent AA amyloidosis in the renal allograft has been documented in patients with tuberculosis, familial Mediterranean fever, ankylosing spondylitis, chronic pyelonephritis and rheumatoid arthritis. De novo AA amyloidosis is rarely described. We report two cases of AA amyloidosis in the renal allograft. Our first case is a 47-year-old male with a history of ankylosing spondylitis who developed end-stage renal disease reportedly from tubulointerstitial nephritis from non-steroidal anti-inflammatory agent use. A biopsy was never performed. One year after transplantation, AA amyloidosis was identified in the femoral head and 8 years post-transplantation, AA amyloidosis was identified in the renal allograft. He was treated with colchicine and adalimumab and has stable renal function at 1 year-follow-up. Our second case is a 57-year-old male with a long history of intravenous drug use and hepatitis C infection who developed end-stage kidney disease due to AA amyloidosis. Our second patient's course was complicated by renal adenovirus, pulmonary aspergillosis and hepatitis C with AA amyloidosis subsequently being identified in the allograft 2.5 years post-transplantation. Renal allograft function remains stable 4-years post-transplantation. These reports describe clinical and pathologic features of two cases of AA amyloidosis presenting with proteinuria and focal involvement of the renal allograft. Oxford University Press 2012-04 /pmc/articles/PMC3341841/ /pubmed/22833808 http://dx.doi.org/10.1093/ckj/sfs019 Text en © The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Contributions
Rojas, Rebecca
Josephson, Michelle A.
Chang, Anthony
Meehan, Shane M.
AA amyloidosis in the renal allograft: a report of two cases and review of the literature
title AA amyloidosis in the renal allograft: a report of two cases and review of the literature
title_full AA amyloidosis in the renal allograft: a report of two cases and review of the literature
title_fullStr AA amyloidosis in the renal allograft: a report of two cases and review of the literature
title_full_unstemmed AA amyloidosis in the renal allograft: a report of two cases and review of the literature
title_short AA amyloidosis in the renal allograft: a report of two cases and review of the literature
title_sort aa amyloidosis in the renal allograft: a report of two cases and review of the literature
topic Original Contributions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341841/
https://www.ncbi.nlm.nih.gov/pubmed/22833808
http://dx.doi.org/10.1093/ckj/sfs019
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