MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients

BACKGROUND: Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. METHODS: We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. RESU...

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Autores principales: Langers, A M J, Verspaget, H W, Hawinkels, L J A C, Kubben, F J G M, van Duijn, W, van der Reijden, J J, Hardwick, J C H, Hommes, D W, Sier, C F M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341861/
https://www.ncbi.nlm.nih.gov/pubmed/22472880
http://dx.doi.org/10.1038/bjc.2012.80
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author Langers, A M J
Verspaget, H W
Hawinkels, L J A C
Kubben, F J G M
van Duijn, W
van der Reijden, J J
Hardwick, J C H
Hommes, D W
Sier, C F M
author_facet Langers, A M J
Verspaget, H W
Hawinkels, L J A C
Kubben, F J G M
van Duijn, W
van der Reijden, J J
Hardwick, J C H
Hommes, D W
Sier, C F M
author_sort Langers, A M J
collection PubMed
description BACKGROUND: Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. METHODS: We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. RESULTS: A high protein expression of MMP-2 as well as MMP-9 in normal mucosa was found to be correlated with worse 5-year survival. The combination of both parameters was an even stronger prognostic factor. These protein levels were found not to be related to the corresponding single nucleotide polymorphisms of MMP-2 (−1306C>T) and MMP-9 (−1562C>T). Multivariate analyses indicated that the MMP-2 and MMP-9 levels in normal mucosa are prognostic for survival, independent of TNM classification. CONCLUSION: MMP-2 and MMP-9 levels in normal mucosa are indicative of the course of disease in colorectal cancer patients.
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spelling pubmed-33418612013-04-24 MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients Langers, A M J Verspaget, H W Hawinkels, L J A C Kubben, F J G M van Duijn, W van der Reijden, J J Hardwick, J C H Hommes, D W Sier, C F M Br J Cancer Short Communication BACKGROUND: Upregulation of the matrix metalloproteinases MMP-2 and MMP-9 in various cancers has been associated with worse survival of the patients. METHODS: We assessed MMP-2 and MMP-9 levels in normal colorectal mucosa from colorectal cancer patients in relation to the course of the disease. RESULTS: A high protein expression of MMP-2 as well as MMP-9 in normal mucosa was found to be correlated with worse 5-year survival. The combination of both parameters was an even stronger prognostic factor. These protein levels were found not to be related to the corresponding single nucleotide polymorphisms of MMP-2 (−1306C>T) and MMP-9 (−1562C>T). Multivariate analyses indicated that the MMP-2 and MMP-9 levels in normal mucosa are prognostic for survival, independent of TNM classification. CONCLUSION: MMP-2 and MMP-9 levels in normal mucosa are indicative of the course of disease in colorectal cancer patients. Nature Publishing Group 2012-04-24 2012-04-03 /pmc/articles/PMC3341861/ /pubmed/22472880 http://dx.doi.org/10.1038/bjc.2012.80 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Langers, A M J
Verspaget, H W
Hawinkels, L J A C
Kubben, F J G M
van Duijn, W
van der Reijden, J J
Hardwick, J C H
Hommes, D W
Sier, C F M
MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients
title MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients
title_full MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients
title_fullStr MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients
title_full_unstemmed MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients
title_short MMP-2 and MMP-9 in normal mucosa are independently associated with outcome of colorectal cancer patients
title_sort mmp-2 and mmp-9 in normal mucosa are independently associated with outcome of colorectal cancer patients
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341861/
https://www.ncbi.nlm.nih.gov/pubmed/22472880
http://dx.doi.org/10.1038/bjc.2012.80
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