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CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients
BACKGROUND: The CXC chemokine receptor (CXCR)7 is involved in tumour development and metastases formation. The aim of the present study was to determine protein expression of CXCR7, its putative co-receptors epidermal growth factor receptor (EGFR) and CXCR4, its predominant ligand CXCL12, their co-d...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341866/ https://www.ncbi.nlm.nih.gov/pubmed/22531719 http://dx.doi.org/10.1038/bjc.2012.110 |
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author | Schrevel, M Karim, R ter Haar, N T van der Burg, S H Trimbos, J B M Z Fleuren, G J Gorter, A Jordanova, E S |
author_facet | Schrevel, M Karim, R ter Haar, N T van der Burg, S H Trimbos, J B M Z Fleuren, G J Gorter, A Jordanova, E S |
author_sort | Schrevel, M |
collection | PubMed |
description | BACKGROUND: The CXC chemokine receptor (CXCR)7 is involved in tumour development and metastases formation. The aim of the present study was to determine protein expression of CXCR7, its putative co-receptors epidermal growth factor receptor (EGFR) and CXCR4, its predominant ligand CXCL12, their co-dependency and their association with survival in cervical cancer patients. METHODS: CXC chemokine receptor 7, EGFR, CXCR4 and CXCL12 expression were determined immunohistochemically in 103 paraffin-embedded, cervical cancers. Subsequently, associations with patient characteristics were assessed and survival analyses were performed. RESULTS: CXC chemokine receptor 7 was expressed by 43% of tumour specimens, in a large majority of cases together with either EGFR or CXCR4 (double positive), or both (triple positive). The CXCR7 expression was associated with tumour size (P=0.013), lymph node metastasis (P=0.001) and EGFR expression (P=0.009). CXC chemokine receptor 7 was independently associated with disease-free survival (hazard ratio (HR)=4.3, 95% confidence intervals (CI) 1.7–11.0, P=0.002), and strongly associated with disease-specific survival (HR=3.9, 95% CI 1.5–10.2, P=0.005). CONCLUSION: CXC chemokine receptor 7 expression predicts poor disease-free and disease-specific survival in cervical cancer patients, and might be a promising new therapeutic marker. In a large majority of cases, CXCR7 is co-expressed with CXCR4 and/or EGFR, supporting the hypothesis that these receptors assist in CXCR7 signal transduction. |
format | Online Article Text |
id | pubmed-3341866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-33418662013-04-24 CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients Schrevel, M Karim, R ter Haar, N T van der Burg, S H Trimbos, J B M Z Fleuren, G J Gorter, A Jordanova, E S Br J Cancer Molecular Diagnostics BACKGROUND: The CXC chemokine receptor (CXCR)7 is involved in tumour development and metastases formation. The aim of the present study was to determine protein expression of CXCR7, its putative co-receptors epidermal growth factor receptor (EGFR) and CXCR4, its predominant ligand CXCL12, their co-dependency and their association with survival in cervical cancer patients. METHODS: CXC chemokine receptor 7, EGFR, CXCR4 and CXCL12 expression were determined immunohistochemically in 103 paraffin-embedded, cervical cancers. Subsequently, associations with patient characteristics were assessed and survival analyses were performed. RESULTS: CXC chemokine receptor 7 was expressed by 43% of tumour specimens, in a large majority of cases together with either EGFR or CXCR4 (double positive), or both (triple positive). The CXCR7 expression was associated with tumour size (P=0.013), lymph node metastasis (P=0.001) and EGFR expression (P=0.009). CXC chemokine receptor 7 was independently associated with disease-free survival (hazard ratio (HR)=4.3, 95% confidence intervals (CI) 1.7–11.0, P=0.002), and strongly associated with disease-specific survival (HR=3.9, 95% CI 1.5–10.2, P=0.005). CONCLUSION: CXC chemokine receptor 7 expression predicts poor disease-free and disease-specific survival in cervical cancer patients, and might be a promising new therapeutic marker. In a large majority of cases, CXCR7 is co-expressed with CXCR4 and/or EGFR, supporting the hypothesis that these receptors assist in CXCR7 signal transduction. Nature Publishing Group 2012-04-24 2012-04-24 /pmc/articles/PMC3341866/ /pubmed/22531719 http://dx.doi.org/10.1038/bjc.2012.110 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by-nc-sa/3.0/From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Molecular Diagnostics Schrevel, M Karim, R ter Haar, N T van der Burg, S H Trimbos, J B M Z Fleuren, G J Gorter, A Jordanova, E S CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients |
title | CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients |
title_full | CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients |
title_fullStr | CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients |
title_full_unstemmed | CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients |
title_short | CXCR7 expression is associated with disease-free and disease-specific survival in cervical cancer patients |
title_sort | cxcr7 expression is associated with disease-free and disease-specific survival in cervical cancer patients |
topic | Molecular Diagnostics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341866/ https://www.ncbi.nlm.nih.gov/pubmed/22531719 http://dx.doi.org/10.1038/bjc.2012.110 |
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