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Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape
Despite the impressive progress over the past decade, in the field of tumor immunology, such as the identification of tumor antigens and antigenic peptides, there are still many obstacles in eliciting an effective immune response to eradicate cancer. It has become increasingly clear that tumor micro...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341970/ https://www.ncbi.nlm.nih.gov/pubmed/22566905 http://dx.doi.org/10.3389/fimmu.2012.00021 |
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author | Chouaib, Salem Messai, Yosra Couve, Sophie Escudier, Bernard Hasmim, Meriem Noman, Muhammad Zaeem |
author_facet | Chouaib, Salem Messai, Yosra Couve, Sophie Escudier, Bernard Hasmim, Meriem Noman, Muhammad Zaeem |
author_sort | Chouaib, Salem |
collection | PubMed |
description | Despite the impressive progress over the past decade, in the field of tumor immunology, such as the identification of tumor antigens and antigenic peptides, there are still many obstacles in eliciting an effective immune response to eradicate cancer. It has become increasingly clear that tumor microenvironment plays a crucial role in the control of immune protection. Tumors have evolved to utilize hypoxic stress to their own advantage by activating key biochemical and cellular pathways that are important in progression, survival, and metastasis. Hypoxia-inducible factor (HIF-1) and vascular endothelial growth factor (VEGF) play a determinant role in promoting tumor cell growth and survival. Hypoxia contributes to immune suppression by activating HIF-1 and VEGF pathways. Accumulating evidence suggests a link between hypoxia and tumor tolerance to immune surveillance through the recruitment of regulatory cells (regulatory T cells and myeloid derived suppressor cells). In this regard, hypoxia (HIF-1α and VEGF) is emerging as an attractive target for cancer therapy. How the microenvironmental hypoxia poses both obstacles and opportunities for new therapeutic immune interventions will be discussed. |
format | Online Article Text |
id | pubmed-3341970 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33419702012-05-07 Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape Chouaib, Salem Messai, Yosra Couve, Sophie Escudier, Bernard Hasmim, Meriem Noman, Muhammad Zaeem Front Immunol Immunology Despite the impressive progress over the past decade, in the field of tumor immunology, such as the identification of tumor antigens and antigenic peptides, there are still many obstacles in eliciting an effective immune response to eradicate cancer. It has become increasingly clear that tumor microenvironment plays a crucial role in the control of immune protection. Tumors have evolved to utilize hypoxic stress to their own advantage by activating key biochemical and cellular pathways that are important in progression, survival, and metastasis. Hypoxia-inducible factor (HIF-1) and vascular endothelial growth factor (VEGF) play a determinant role in promoting tumor cell growth and survival. Hypoxia contributes to immune suppression by activating HIF-1 and VEGF pathways. Accumulating evidence suggests a link between hypoxia and tumor tolerance to immune surveillance through the recruitment of regulatory cells (regulatory T cells and myeloid derived suppressor cells). In this regard, hypoxia (HIF-1α and VEGF) is emerging as an attractive target for cancer therapy. How the microenvironmental hypoxia poses both obstacles and opportunities for new therapeutic immune interventions will be discussed. Frontiers Research Foundation 2012-02-23 /pmc/articles/PMC3341970/ /pubmed/22566905 http://dx.doi.org/10.3389/fimmu.2012.00021 Text en Copyright © 2012 Chouaib, Messai, Couve, Escudier, Hasmim and Noman. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Immunology Chouaib, Salem Messai, Yosra Couve, Sophie Escudier, Bernard Hasmim, Meriem Noman, Muhammad Zaeem Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape |
title | Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape |
title_full | Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape |
title_fullStr | Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape |
title_full_unstemmed | Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape |
title_short | Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape |
title_sort | hypoxia promotes tumor growth in linking angiogenesis to immune escape |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341970/ https://www.ncbi.nlm.nih.gov/pubmed/22566905 http://dx.doi.org/10.3389/fimmu.2012.00021 |
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