Why Do Some T Cell Receptor Cytoplasmic Domains Associate with the Plasma Membrane?

Based on studies in model systems it has been proposed that the cytoplasmic domains of T cell receptor signaling subunits that have polybasic motifs associate with the plasma membrane, and that this regulates their phosphorylation. Recent experiments in more physiological systems have confirmed memb...

Descripción completa

Detalles Bibliográficos
Autores principales: van der Merwe, P. Anton, Zhang, Hao, Cordoba, Shaun-Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341999/
https://www.ncbi.nlm.nih.gov/pubmed/22566913
http://dx.doi.org/10.3389/fimmu.2012.00029
_version_ 1782231610348797952
author van der Merwe, P. Anton
Zhang, Hao
Cordoba, Shaun-Paul
author_facet van der Merwe, P. Anton
Zhang, Hao
Cordoba, Shaun-Paul
author_sort van der Merwe, P. Anton
collection PubMed
description Based on studies in model systems it has been proposed that the cytoplasmic domains of T cell receptor signaling subunits that have polybasic motifs associate with the plasma membrane, and that this regulates their phosphorylation. Recent experiments in more physiological systems have confirmed membrane association but raised questions as to its function.
format Online
Article
Text
id pubmed-3341999
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Frontiers Research Foundation
record_format MEDLINE/PubMed
spelling pubmed-33419992012-05-07 Why Do Some T Cell Receptor Cytoplasmic Domains Associate with the Plasma Membrane? van der Merwe, P. Anton Zhang, Hao Cordoba, Shaun-Paul Front Immunol Immunology Based on studies in model systems it has been proposed that the cytoplasmic domains of T cell receptor signaling subunits that have polybasic motifs associate with the plasma membrane, and that this regulates their phosphorylation. Recent experiments in more physiological systems have confirmed membrane association but raised questions as to its function. Frontiers Research Foundation 2012-02-23 /pmc/articles/PMC3341999/ /pubmed/22566913 http://dx.doi.org/10.3389/fimmu.2012.00029 Text en Copyright © 2012 Merwe, Zhang and Cordoba. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Immunology
van der Merwe, P. Anton
Zhang, Hao
Cordoba, Shaun-Paul
Why Do Some T Cell Receptor Cytoplasmic Domains Associate with the Plasma Membrane?
title Why Do Some T Cell Receptor Cytoplasmic Domains Associate with the Plasma Membrane?
title_full Why Do Some T Cell Receptor Cytoplasmic Domains Associate with the Plasma Membrane?
title_fullStr Why Do Some T Cell Receptor Cytoplasmic Domains Associate with the Plasma Membrane?
title_full_unstemmed Why Do Some T Cell Receptor Cytoplasmic Domains Associate with the Plasma Membrane?
title_short Why Do Some T Cell Receptor Cytoplasmic Domains Associate with the Plasma Membrane?
title_sort why do some t cell receptor cytoplasmic domains associate with the plasma membrane?
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341999/
https://www.ncbi.nlm.nih.gov/pubmed/22566913
http://dx.doi.org/10.3389/fimmu.2012.00029
work_keys_str_mv AT vandermerwepanton whydosometcellreceptorcytoplasmicdomainsassociatewiththeplasmamembrane
AT zhanghao whydosometcellreceptorcytoplasmicdomainsassociatewiththeplasmamembrane
AT cordobashaunpaul whydosometcellreceptorcytoplasmicdomainsassociatewiththeplasmamembrane

Ejemplares similares