Models of Aire-Dependent Gene Regulation for Thymic Negative Selection

Mutations in the autoimmune regulator (AIRE) gene lead to autoimmune polyendocrinopathy syndrome type 1 (APS1), characterized by the development of multi-organ autoimmune damage. The mechanism by which defects in AIRE result in autoimmunity has been the subject of intense scrutiny. At the cellular l...

Descripción completa

Detalles Bibliográficos
Autores principales: Danso-Abeam, Dina, Humblet-Baron, Stephanie, Dooley, James, Liston, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342030/
https://www.ncbi.nlm.nih.gov/pubmed/22566805
http://dx.doi.org/10.3389/fimmu.2011.00014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342030/
https://www.ncbi.nlm.nih.gov/pubmed/22566805
http://dx.doi.org/10.3389/fimmu.2011.00014

Ejemplares similares