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Models of Aire-Dependent Gene Regulation for Thymic Negative Selection

Mutations in the autoimmune regulator (AIRE) gene lead to autoimmune polyendocrinopathy syndrome type 1 (APS1), characterized by the development of multi-organ autoimmune damage. The mechanism by which defects in AIRE result in autoimmunity has been the subject of intense scrutiny. At the cellular l...

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Detalles Bibliográficos
Autores principales:	Danso-Abeam, Dina, Humblet-Baron, Stephanie, Dooley, James, Liston, Adrian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2011
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342030/ https://www.ncbi.nlm.nih.gov/pubmed/22566805 http://dx.doi.org/10.3389/fimmu.2011.00014

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