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Dominant Role of CD80–CD86 Over CD40 and ICOSL in the Massive Polyclonal B Cell Activation Mediated by LAT(Y136F) CD4(+) T Cells

Coordinated interactions between T and B cells are crucial for inducing physiological B cell responses. Mutant mice in which tyrosine 136 of linker for activation of T cell (LAT) is replaced by a phenylalanine (Lat(Y136F)) exhibit a strong CD4(+) T cell proliferation in the absence of intended immun...

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Detalles Bibliográficos
Autores principales:	Chevrier, Stéphane, Genton, Céline, Malissen, Bernard, Malissen, Marie, Acha-Orbea, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342035/ https://www.ncbi.nlm.nih.gov/pubmed/22566911 http://dx.doi.org/10.3389/fimmu.2012.00027

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