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Bilateral multifocal Warthin's tumors in upper neck lymph nodes. report of a case and brief review of the literature

Cystadenolymphomas (Warthin's tumors) are the second most frequent lesions of the parotid gland. Due to their benign clinical behavior, the low rates of recurrence and malignant transformation they were classified as tumor-like lesions. In addition, a polyclonal growth of the epithelial compone...

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Autores principales: Naujoks, Christian, Sproll, Christoph, Singh, Daman Deep, Heikaus, Sebastian, Depprich, Rita, Kübler, Norbert R, Handschel, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342104/
https://www.ncbi.nlm.nih.gov/pubmed/22472434
http://dx.doi.org/10.1186/1746-160X-8-11
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author Naujoks, Christian
Sproll, Christoph
Singh, Daman Deep
Heikaus, Sebastian
Depprich, Rita
Kübler, Norbert R
Handschel, Jörg
author_facet Naujoks, Christian
Sproll, Christoph
Singh, Daman Deep
Heikaus, Sebastian
Depprich, Rita
Kübler, Norbert R
Handschel, Jörg
author_sort Naujoks, Christian
collection PubMed
description Cystadenolymphomas (Warthin's tumors) are the second most frequent lesions of the parotid gland. Due to their benign clinical behavior, the low rates of recurrence and malignant transformation they were classified as tumor-like lesions. In addition, a polyclonal growth of the epithelial components of the tumor could be detected. Warthin's tumors occur bilateral in 7-10%, whereas a multifocal appearance is extremely rare. Even if the pathogenesis is still unclear a heterotopia of salivary tissue during embryogenesis is the most likely explanation for the origin of these tumors in the upper neck and periparotideal region. Here we present a rare case of bilateral, multifocal, extraglandular Warthin's tumors in lymph nodes of the upper neck and give a brief review of the literature. If a primary malignancy can be excluded by a careful staging procedure prior to the operation an isolated excision of the lesions of the neck is the adequate treatment.
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spelling pubmed-33421042012-05-03 Bilateral multifocal Warthin's tumors in upper neck lymph nodes. report of a case and brief review of the literature Naujoks, Christian Sproll, Christoph Singh, Daman Deep Heikaus, Sebastian Depprich, Rita Kübler, Norbert R Handschel, Jörg Head Face Med Case Report Cystadenolymphomas (Warthin's tumors) are the second most frequent lesions of the parotid gland. Due to their benign clinical behavior, the low rates of recurrence and malignant transformation they were classified as tumor-like lesions. In addition, a polyclonal growth of the epithelial components of the tumor could be detected. Warthin's tumors occur bilateral in 7-10%, whereas a multifocal appearance is extremely rare. Even if the pathogenesis is still unclear a heterotopia of salivary tissue during embryogenesis is the most likely explanation for the origin of these tumors in the upper neck and periparotideal region. Here we present a rare case of bilateral, multifocal, extraglandular Warthin's tumors in lymph nodes of the upper neck and give a brief review of the literature. If a primary malignancy can be excluded by a careful staging procedure prior to the operation an isolated excision of the lesions of the neck is the adequate treatment. BioMed Central 2012-04-03 /pmc/articles/PMC3342104/ /pubmed/22472434 http://dx.doi.org/10.1186/1746-160X-8-11 Text en Copyright ©2012 Naujoks et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Naujoks, Christian
Sproll, Christoph
Singh, Daman Deep
Heikaus, Sebastian
Depprich, Rita
Kübler, Norbert R
Handschel, Jörg
Bilateral multifocal Warthin's tumors in upper neck lymph nodes. report of a case and brief review of the literature
title Bilateral multifocal Warthin's tumors in upper neck lymph nodes. report of a case and brief review of the literature
title_full Bilateral multifocal Warthin's tumors in upper neck lymph nodes. report of a case and brief review of the literature
title_fullStr Bilateral multifocal Warthin's tumors in upper neck lymph nodes. report of a case and brief review of the literature
title_full_unstemmed Bilateral multifocal Warthin's tumors in upper neck lymph nodes. report of a case and brief review of the literature
title_short Bilateral multifocal Warthin's tumors in upper neck lymph nodes. report of a case and brief review of the literature
title_sort bilateral multifocal warthin's tumors in upper neck lymph nodes. report of a case and brief review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342104/
https://www.ncbi.nlm.nih.gov/pubmed/22472434
http://dx.doi.org/10.1186/1746-160X-8-11
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