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The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis
BACKGROUND: Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis. METHODS: We conducted a systematic review of m...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342117/ https://www.ncbi.nlm.nih.gov/pubmed/22463676 http://dx.doi.org/10.1186/1472-6823-12-2 |
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author | Murad, M Hassan Hazem, Ahmad Coto-Yglesias, Fernando Dzyubak, Svitlana Gupta, Shabnum Bancos, Irina Lane, Melanie A Erwin, Patricia J Berglund, Lars Elraiyah, Tarig Montori, Victor M |
author_facet | Murad, M Hassan Hazem, Ahmad Coto-Yglesias, Fernando Dzyubak, Svitlana Gupta, Shabnum Bancos, Irina Lane, Melanie A Erwin, Patricia J Berglund, Lars Elraiyah, Tarig Montori, Victor M |
author_sort | Murad, M Hassan |
collection | PubMed |
description | BACKGROUND: Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis. METHODS: We conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects model. Studies eligible for this review followed patients longitudinally and evaluated quantitatively the association of fasting hypertriglyceridemia with the outcomes of interest. Reviewers working independently and in duplicate reviewed studies and extracted data. RESULTS: 35 studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment. Fasting hypertriglyceridemia was significantly associated with cardiovascular death (odds ratios (OR) 1.80; 95% confidence interval (CI) 1.31-2.49), cardiovascular events (OR, 1.37; 95% CI, 1.23-1.53), myocardial infarction (OR, 1.31; 95% CI, 1.15-1.49), and pancreatitis (OR, 3.96; 95% CI, 1.27-12.34, in one study only). The association with all-cause mortality was not statistically significant. CONCLUSIONS: The current evidence suggests that fasting hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis. Précis: hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis |
format | Online Article Text |
id | pubmed-3342117 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-33421172012-05-03 The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis Murad, M Hassan Hazem, Ahmad Coto-Yglesias, Fernando Dzyubak, Svitlana Gupta, Shabnum Bancos, Irina Lane, Melanie A Erwin, Patricia J Berglund, Lars Elraiyah, Tarig Montori, Victor M BMC Endocr Disord Research Article BACKGROUND: Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis. METHODS: We conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects model. Studies eligible for this review followed patients longitudinally and evaluated quantitatively the association of fasting hypertriglyceridemia with the outcomes of interest. Reviewers working independently and in duplicate reviewed studies and extracted data. RESULTS: 35 studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment. Fasting hypertriglyceridemia was significantly associated with cardiovascular death (odds ratios (OR) 1.80; 95% confidence interval (CI) 1.31-2.49), cardiovascular events (OR, 1.37; 95% CI, 1.23-1.53), myocardial infarction (OR, 1.31; 95% CI, 1.15-1.49), and pancreatitis (OR, 3.96; 95% CI, 1.27-12.34, in one study only). The association with all-cause mortality was not statistically significant. CONCLUSIONS: The current evidence suggests that fasting hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis. Précis: hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis BioMed Central 2012-03-31 /pmc/articles/PMC3342117/ /pubmed/22463676 http://dx.doi.org/10.1186/1472-6823-12-2 Text en Copyright ©2012 Murad et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Murad, M Hassan Hazem, Ahmad Coto-Yglesias, Fernando Dzyubak, Svitlana Gupta, Shabnum Bancos, Irina Lane, Melanie A Erwin, Patricia J Berglund, Lars Elraiyah, Tarig Montori, Victor M The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis |
title | The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis |
title_full | The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis |
title_fullStr | The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis |
title_full_unstemmed | The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis |
title_short | The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis |
title_sort | association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342117/ https://www.ncbi.nlm.nih.gov/pubmed/22463676 http://dx.doi.org/10.1186/1472-6823-12-2 |
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