Cross-phase modulation spectral shifting: nonlinear phase contrast in a pump-probe microscope

Microscopy with nonlinear phase contrast is achieved by a simple modification to a nonlinear pump-probe microscope. The technique measures cross-phase modulation by detecting a pump-induced spectral shift in the probe pulse. Images with nonlinear phase contrast are acquired both in transparent and a...

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Detalles Bibliográficos
Autores principales: Wilson, Jesse W., Samineni, Prathyush, Warren, Warren S., Fischer, Martin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2012
Materias:
Microscopy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342192/
https://www.ncbi.nlm.nih.gov/pubmed/22567580
http://dx.doi.org/10.1364/BOE.3.000854
Descripción
Sumario:Microscopy with nonlinear phase contrast is achieved by a simple modification to a nonlinear pump-probe microscope. The technique measures cross-phase modulation by detecting a pump-induced spectral shift in the probe pulse. Images with nonlinear phase contrast are acquired both in transparent and absorptive media. In paraffin-embedded biopsy sections, cross-phase modulation complements the chemically-specific pump-probe images with structural context.

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