Speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility

Optical coherence tomography (OCT) has the combined advantage of high temporal (µsec) and spatial (<10µm) resolution. These features make it an attractive tool to study the dynamic relationship between neural activity and the surrounding blood vessels in the spinal cord, a topic that is poorly un...

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Detalles Bibliográficos
Autores principales: Cadotte, David W., Mariampillai, Adrian, Cadotte, Adam, Lee, Kenneth K. C., Kiehl, Tim-Rasmus, Wilson, Brian C., Fehlings, Michael G., Yang, Victor X. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2012
Materias:
Optical Coherence Tomography
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342196/
https://www.ncbi.nlm.nih.gov/pubmed/22567584
http://dx.doi.org/10.1364/BOE.3.000911
Descripción
Sumario:Optical coherence tomography (OCT) has the combined advantage of high temporal (µsec) and spatial (<10µm) resolution. These features make it an attractive tool to study the dynamic relationship between neural activity and the surrounding blood vessels in the spinal cord, a topic that is poorly understood. Here we present work that aims to optimize an in vivo OCT imaging model of the rodent spinal cord. In this study we image the microvascular networks of both rats and mice using speckle variance OCT. This is the first report of depth resolved imaging of the in vivo spinal cord using an entirely endogenous contrast mechanism.

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