Speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility

Optical coherence tomography (OCT) has the combined advantage of high temporal (µsec) and spatial (<10µm) resolution. These features make it an attractive tool to study the dynamic relationship between neural activity and the surrounding blood vessels in the spinal cord, a topic that is poorly un...

Descripción completa

Detalles Bibliográficos
Autores principales: Cadotte, David W., Mariampillai, Adrian, Cadotte, Adam, Lee, Kenneth K. C., Kiehl, Tim-Rasmus, Wilson, Brian C., Fehlings, Michael G., Yang, Victor X. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Optical Society of America 2012
Materias:
Optical Coherence Tomography
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342196/
https://www.ncbi.nlm.nih.gov/pubmed/22567584
http://dx.doi.org/10.1364/BOE.3.000911
_version_ 1782231652247797760
author Cadotte, David W.
Mariampillai, Adrian
Cadotte, Adam
Lee, Kenneth K. C.
Kiehl, Tim-Rasmus
Wilson, Brian C.
Fehlings, Michael G.
Yang, Victor X. D.
author_facet Cadotte, David W.
Mariampillai, Adrian
Cadotte, Adam
Lee, Kenneth K. C.
Kiehl, Tim-Rasmus
Wilson, Brian C.
Fehlings, Michael G.
Yang, Victor X. D.
author_sort Cadotte, David W.
collection PubMed
description Optical coherence tomography (OCT) has the combined advantage of high temporal (µsec) and spatial (<10µm) resolution. These features make it an attractive tool to study the dynamic relationship between neural activity and the surrounding blood vessels in the spinal cord, a topic that is poorly understood. Here we present work that aims to optimize an in vivo OCT imaging model of the rodent spinal cord. In this study we image the microvascular networks of both rats and mice using speckle variance OCT. This is the first report of depth resolved imaging of the in vivo spinal cord using an entirely endogenous contrast mechanism.
format Online
Article
Text
id pubmed-3342196
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Optical Society of America
record_format MEDLINE/PubMed
spelling pubmed-33421962012-05-07 Speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility Cadotte, David W. Mariampillai, Adrian Cadotte, Adam Lee, Kenneth K. C. Kiehl, Tim-Rasmus Wilson, Brian C. Fehlings, Michael G. Yang, Victor X. D. Biomed Opt Express Optical Coherence Tomography Optical coherence tomography (OCT) has the combined advantage of high temporal (µsec) and spatial (<10µm) resolution. These features make it an attractive tool to study the dynamic relationship between neural activity and the surrounding blood vessels in the spinal cord, a topic that is poorly understood. Here we present work that aims to optimize an in vivo OCT imaging model of the rodent spinal cord. In this study we image the microvascular networks of both rats and mice using speckle variance OCT. This is the first report of depth resolved imaging of the in vivo spinal cord using an entirely endogenous contrast mechanism. Optical Society of America 2012-04-10 /pmc/articles/PMC3342196/ /pubmed/22567584 http://dx.doi.org/10.1364/BOE.3.000911 Text en ©2012 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.
spellingShingle Optical Coherence Tomography
Cadotte, David W.
Mariampillai, Adrian
Cadotte, Adam
Lee, Kenneth K. C.
Kiehl, Tim-Rasmus
Wilson, Brian C.
Fehlings, Michael G.
Yang, Victor X. D.
Speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility
title Speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility
title_full Speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility
title_fullStr Speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility
title_full_unstemmed Speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility
title_short Speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility
title_sort speckle variance optical coherence tomography of the rodent spinal cord: in vivo feasibility
topic Optical Coherence Tomography
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342196/
https://www.ncbi.nlm.nih.gov/pubmed/22567584
http://dx.doi.org/10.1364/BOE.3.000911
work_keys_str_mv AT cadottedavidw specklevarianceopticalcoherencetomographyoftherodentspinalcordinvivofeasibility
AT mariampillaiadrian specklevarianceopticalcoherencetomographyoftherodentspinalcordinvivofeasibility
AT cadotteadam specklevarianceopticalcoherencetomographyoftherodentspinalcordinvivofeasibility
AT leekennethkc specklevarianceopticalcoherencetomographyoftherodentspinalcordinvivofeasibility
AT kiehltimrasmus specklevarianceopticalcoherencetomographyoftherodentspinalcordinvivofeasibility
AT wilsonbrianc specklevarianceopticalcoherencetomographyoftherodentspinalcordinvivofeasibility
AT fehlingsmichaelg specklevarianceopticalcoherencetomographyoftherodentspinalcordinvivofeasibility
AT yangvictorxd specklevarianceopticalcoherencetomographyoftherodentspinalcordinvivofeasibility

Ejemplares similares