Abnormal Intracellular Accumulation and Extracellular Aβ Deposition in Idiopathic and Dup15q11.2-q13 Autism Spectrum Disorders

BACKGROUND: It has been shown that amyloid ß (Aβ), a product of proteolytic cleavage of the amyloid β precursor protein (APP), accumulates in neuronal cytoplasm in non-affected individuals in a cell type–specific amount. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we found that the percent...

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Detalles Bibliográficos
Autores principales: Wegiel, Jerzy, Frackowiak, Janusz, Mazur-Kolecka, Bozena, Schanen, N. Carolyn, Cook, Edwin H., Sigman, Marian, Brown, W. Ted, Kuchna, Izabela, Wegiel, Jarek, Nowicki, Krzysztof, Imaki, Humi, Ma, Shuang Yong, Chauhan, Abha, Chauhan, Ved, Miller, David L., Mehta, Pankaj D., Flory, Michael, Cohen, Ira L., London, Eric, Reisberg, Barry, de Leon, Mony J., Wisniewski, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342283/
https://www.ncbi.nlm.nih.gov/pubmed/22567102
http://dx.doi.org/10.1371/journal.pone.0035414

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