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SPARC Overexpression Inhibits Cell Proliferation in Neuroblastoma and Is Partly Mediated by Tumor Suppressor Protein PTEN and AKT

Secreted protein acidic and rich in cysteine (SPARC) is also known as BM-40 or Osteonectin, a multi-functional protein modulating cell–cell and cell–matrix interactions. In cancer, SPARC is not only linked with a highly aggressive phenotype, but it also acts as a tumor suppressor. In the present stu...

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Detalles Bibliográficos
Autores principales:	Bhoopathi, Praveen, Gorantla, Bharathi, Sailaja, G. S., Gondi, Christopher S., Gujrati, Meena, Klopfenstein, Jeffrey D., Rao, Jasti S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342296/ https://www.ncbi.nlm.nih.gov/pubmed/22567126 http://dx.doi.org/10.1371/journal.pone.0036093

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