Cargando…

The TGF-β/Smad Repressor TG-Interacting Factor 1 (TGIF1) Plays a Role in Radiation-Induced Intestinal Injury Independently of a Smad Signaling Pathway

Despite advances in radiation delivery protocols, exposure of normal tissues during the course of radiation therapy remains a limiting factor of cancer treatment. If the canonical TGF-β/Smad pathway has been extensively studied and implicated in the development of radiation damage in various organs,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hneino, Mohammad, François, Agnes, Buard, Valerie, Tarlet, Georges, Abderrahmani, Rym, Blirando, Karl, Hoodless, Pamela A., Benderitter, Marc, Milliat, Fabien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342305/ https://www.ncbi.nlm.nih.gov/pubmed/22567107 http://dx.doi.org/10.1371/journal.pone.0035672

Ejemplares similares

PAI-1-Dependent Endothelial Cell Death Determines Severity of Radiation-Induced Intestinal Injury
por: Abderrahmani, Rym, et al.
Publicado: (2012)

TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling
por: Guca, Ewelina, et al.
Publicado: (2018)

HIF-1α Deletion in the Endothelium, but Not in the Epithelium, Protects From Radiation-Induced Enteritis
por: Toullec, Aurore, et al.
Publicado: (2017)

In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury
por: Rannou, Emilie, et al.
Publicado: (2015)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas
por: Zhenye, Li, et al.
Publicado: (2014)

Temporal clustering analysis of endothelial cell gene expression following exposure to a conventional radiotherapy dose fraction using Gaussian process clustering
por: Heinonen, Markus, et al.
Publicado: (2018)

Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancer
por: Weng, Ching-Chieh, et al.
Publicado: (2019)

Tgif1 and Tgif2 Regulate Axial Patterning in Mouse
por: Melhuish, Tiffany A., et al.
Publicado: (2016)

Preclinical Model of Stereotactic Ablative Lung Irradiation Using Arc Delivery in the Mouse: Is Fractionation Worthwhile?
por: Bertho, Annaïg, et al.
Publicado: (2021)

Premature Senescence and Increased TGFβ Signaling in the Absence of Tgif1
por: Zerlanko, Brad J., et al.
Publicado: (2012)

TGF‐β1 promotes gap junctions formation in chondrocytes via Smad3/Smad4 signalling
por: Wang, Qingxuan, et al.
Publicado: (2018)

Xbra and Smad-1 cooperate to activate the transcription of neural repressor ventx1.1 in Xenopus embryos
por: Kumar, Shiv, et al.
Publicado: (2018)

Rejuvenation by inhibiting TGF-β1/pSmad signaling
por: Corder, Elizabeth H., et al.
Publicado: (2015)

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
por: Hough, Chris, et al.
Publicado: (2012)

Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
por: Zhang, Zihui, et al.
Publicado: (2020)

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling
por: Aragón, Eric, et al.
Publicado: (2019)

Latency-Associated Transcript-Derived MicroRNAs in Herpes Simplex Virus Type 1 Target SMAD3 and SMAD4 in TGF-β/Smad Signaling Pathway
por: Shojaei Jeshvaghani, Zahra, et al.
Publicado: (2021)

TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone
por: Saito, Hiroaki, et al.
Publicado: (2019)

Effect of progesterone on Smad signaling and TGF-β/Smad-regulated genes in lung epithelial cells
por: Kunzmann, Steffen, et al.
Publicado: (2018)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

BRCA1 Interacts with Smad3 and Regulates Smad3-Mediated TGF-β Signaling during Oxidative Stress Responses
por: Li, Huchun, et al.
Publicado: (2009)

Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice
por: Mintet, Elodie, et al.
Publicado: (2017)

Immunohistochemical Expression of TGF-Β1, SMAD4, SMAD7, TGFβRII and CD68-Positive TAM Densities in Papillary Thyroid Cancer
por: Ivanova, Koni, et al.
Publicado: (2018)

TGFβ1 Attenuates Expression of Prolactin and IGFBP-1 in Decidualized Endometrial Stromal Cells by Both SMAD-Dependent and SMAD-Independent Pathways
por: Kane, Nicole M., et al.
Publicado: (2010)

Somatic SMAD3-activating mutations cause melorheostosis by up-regulating the TGF-β/SMAD pathway
por: Kang, Heeseog, et al.
Publicado: (2020)

Smad7-overexpressing rat BMSCs inhibit the fibrosis of hepatic stellate cells by regulating the TGF-β1/Smad signaling pathway
por: Wu, Shi-Pin, et al.
Publicado: (2017)

TGF-β and TGF-β/Smad Signaling in the Interactions between Echinococcus multilocularis and Its Hosts
por: Wang, Junhua, et al.
Publicado: (2013)

Smad4-mediated TGF-β signaling in tumorigenesis
por: Yang, Guan, et al.
Publicado: (2010)

The regulation of TGF-β/SMAD signaling by protein deubiquitination
por: Zhang, Juan, et al.
Publicado: (2014)

The role of TGF-β/SMAD4 signaling in cancer
por: Zhao, Ming, et al.
Publicado: (2018)

TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
por: Yu, Xiao-Yong, et al.
Publicado: (2022)

TGF-β1/Smads and miR-21 in Renal Fibrosis and Inflammation
por: Loboda, Agnieszka, et al.
Publicado: (2016)

Critical Role of Smad and AP-1 Complexes in TGF-β-Dependent Apoptosis
por: Yamamura, Yasuko, et al.
Publicado: (2001)

Celastrol inhibits colorectal cancer through TGF-β1/Smad signaling
por: Jiang, Zhitao, et al.
Publicado: (2019)

TGF-β1-Smad signaling pathways are not required for epidermal LC homeostasis
por: Li, Guihua, et al.
Publicado: (2016)

NANOG regulates the proliferation of PCSCs via the TGF-β1/SMAD pathway
por: Liu, Changming, et al.
Publicado: (2020)

Aspirin attenuates liver fibrosis by suppressing TGF-β1/Smad signaling
por: Sun, Yimin, et al.
Publicado: (2022)

TGF-β1/Smad Signalling in Proliferative Glomerulonephritis Associated with Autoimmune Diseases
por: Chalkia, Aglaia, et al.
Publicado: (2022)

Spatio-Temporal Distribution of Smads and Role of Smads/TGF-β/BMP-4 in the Regulation of Mouse Bladder Organogenesis
por: Islam, Syed S., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_vbdt0m034ic7ucno8me96tec8l