Recognition of a High Affinity MHC Class I-Restricted Epitope of Myelin Oligodendrocyte Glycoprotein by CD8(+) T Cells Derived from Autoantigen-Deficient Mice

CD4(+) T cells have a well-defined pathogenic role in experimental autoimmune encephalomyelitis, the rodent model of multiple sclerosis (MS), yet CD8(+) T cells are commonly found in MS lesions. To determine whether immunological tolerance might impact differently on CD4(+) versus CD8(+) T cells, we...

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Detalles Bibliográficos
Autores principales: Leech, Melanie D., Carrillo-Vico, Antonio, Liblau, Roland S., Anderton, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342349/
https://www.ncbi.nlm.nih.gov/pubmed/22566807
http://dx.doi.org/10.3389/fimmu.2011.00017

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