The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells

The immuno-regulatory mechanisms of IL-10-producing type 1 regulatory T (Tr1) cells have been widely studied over the years. However, several recent discoveries have shed new light on the cellular and molecular mechanisms that human Tr1 cells use to control immune responses and induce tolerance. In...

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Detalles Bibliográficos
Autores principales: Gregori, Silvia, Goudy, Kevin S., Roncarolo, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342353/
https://www.ncbi.nlm.nih.gov/pubmed/22566914
http://dx.doi.org/10.3389/fimmu.2012.00030
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author Gregori, Silvia
Goudy, Kevin S.
Roncarolo, Maria Grazia
author_facet Gregori, Silvia
Goudy, Kevin S.
Roncarolo, Maria Grazia
author_sort Gregori, Silvia
collection PubMed
description The immuno-regulatory mechanisms of IL-10-producing type 1 regulatory T (Tr1) cells have been widely studied over the years. However, several recent discoveries have shed new light on the cellular and molecular mechanisms that human Tr1 cells use to control immune responses and induce tolerance. In this review we outline the well known and newly discovered regulatory properties of human Tr1 cells and provide an in-depth comparison of the known suppressor mechanisms of Tr1 cells with FOXP3(+) T(reg). We also highlight the role that Tr1 cells play in promoting and maintaining tolerance in autoimmunity, allergy, and transplantation.
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spelling pubmed-33423532012-05-07 The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells Gregori, Silvia Goudy, Kevin S. Roncarolo, Maria Grazia Front Immunol Immunology The immuno-regulatory mechanisms of IL-10-producing type 1 regulatory T (Tr1) cells have been widely studied over the years. However, several recent discoveries have shed new light on the cellular and molecular mechanisms that human Tr1 cells use to control immune responses and induce tolerance. In this review we outline the well known and newly discovered regulatory properties of human Tr1 cells and provide an in-depth comparison of the known suppressor mechanisms of Tr1 cells with FOXP3(+) T(reg). We also highlight the role that Tr1 cells play in promoting and maintaining tolerance in autoimmunity, allergy, and transplantation. Frontiers Research Foundation 2012-02-29 /pmc/articles/PMC3342353/ /pubmed/22566914 http://dx.doi.org/10.3389/fimmu.2012.00030 Text en Copyright © 2012 Gregori, Goudy and Roncarolo. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Immunology
Gregori, Silvia
Goudy, Kevin S.
Roncarolo, Maria Grazia
The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells
title The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells
title_full The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells
title_fullStr The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells
title_full_unstemmed The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells
title_short The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells
title_sort cellular and molecular mechanisms of immuno-suppression by human type 1 regulatory t cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342353/
https://www.ncbi.nlm.nih.gov/pubmed/22566914
http://dx.doi.org/10.3389/fimmu.2012.00030
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