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The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System

While dendritic cells (DC) are central to the induction and regulation of adaptive immunity, these cells are very heterogenous and specific subsets can be characterized based on the expression of cell surface markers and functional properties. Intestinal CD103(+) DCs are the subject of particular in...

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Autores principales: Ruane, Darren Thomas, Lavelle, Ed C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342356/
https://www.ncbi.nlm.nih.gov/pubmed/22566815
http://dx.doi.org/10.3389/fimmu.2011.00025
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author Ruane, Darren Thomas
Lavelle, Ed C.
author_facet Ruane, Darren Thomas
Lavelle, Ed C.
author_sort Ruane, Darren Thomas
collection PubMed
description While dendritic cells (DC) are central to the induction and regulation of adaptive immunity, these cells are very heterogenous and specific subsets can be characterized based on the expression of cell surface markers and functional properties. Intestinal CD103(+) DCs are the subject of particular interest due to their role in regulating mucosal immunity. Since the epithelial surfaces are constantly exposed to a high antigenic load, tight regulation of innate and adaptive intestinal immune responses is vital as intestinal inflammation can have detrimental consequences for the host. Strategically positioned within the lamina propria, CD103(+) DCs play an important role in maintaining intestinal immune homeostasis. These cells are required for the induction of tolerogenic immune responses and imprinting gut homing phenotypic changes on antigen-specific T cells. Recent insights into their development and regulatory properties have revealed additional immunoregulatory roles and further highlighted their importance for intestinal immunity. In this review we discuss the nature of the intestinal CD103(+) DC population and the emerging roles of these cells in the regulation of mucosal immunity.
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spelling pubmed-33423562012-05-07 The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System Ruane, Darren Thomas Lavelle, Ed C. Front Immunol Immunology While dendritic cells (DC) are central to the induction and regulation of adaptive immunity, these cells are very heterogenous and specific subsets can be characterized based on the expression of cell surface markers and functional properties. Intestinal CD103(+) DCs are the subject of particular interest due to their role in regulating mucosal immunity. Since the epithelial surfaces are constantly exposed to a high antigenic load, tight regulation of innate and adaptive intestinal immune responses is vital as intestinal inflammation can have detrimental consequences for the host. Strategically positioned within the lamina propria, CD103(+) DCs play an important role in maintaining intestinal immune homeostasis. These cells are required for the induction of tolerogenic immune responses and imprinting gut homing phenotypic changes on antigen-specific T cells. Recent insights into their development and regulatory properties have revealed additional immunoregulatory roles and further highlighted their importance for intestinal immunity. In this review we discuss the nature of the intestinal CD103(+) DC population and the emerging roles of these cells in the regulation of mucosal immunity. Frontiers Research Foundation 2011-07-01 /pmc/articles/PMC3342356/ /pubmed/22566815 http://dx.doi.org/10.3389/fimmu.2011.00025 Text en Copyright © 2011 Ruane and Lavelle. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
spellingShingle Immunology
Ruane, Darren Thomas
Lavelle, Ed C.
The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System
title The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System
title_full The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System
title_fullStr The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System
title_full_unstemmed The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System
title_short The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System
title_sort role of cd103(+) dendritic cells in the intestinal mucosal immune system
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342356/
https://www.ncbi.nlm.nih.gov/pubmed/22566815
http://dx.doi.org/10.3389/fimmu.2011.00025
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