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The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System
While dendritic cells (DC) are central to the induction and regulation of adaptive immunity, these cells are very heterogenous and specific subsets can be characterized based on the expression of cell surface markers and functional properties. Intestinal CD103(+) DCs are the subject of particular in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Research Foundation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342356/ https://www.ncbi.nlm.nih.gov/pubmed/22566815 http://dx.doi.org/10.3389/fimmu.2011.00025 |
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author | Ruane, Darren Thomas Lavelle, Ed C. |
author_facet | Ruane, Darren Thomas Lavelle, Ed C. |
author_sort | Ruane, Darren Thomas |
collection | PubMed |
description | While dendritic cells (DC) are central to the induction and regulation of adaptive immunity, these cells are very heterogenous and specific subsets can be characterized based on the expression of cell surface markers and functional properties. Intestinal CD103(+) DCs are the subject of particular interest due to their role in regulating mucosal immunity. Since the epithelial surfaces are constantly exposed to a high antigenic load, tight regulation of innate and adaptive intestinal immune responses is vital as intestinal inflammation can have detrimental consequences for the host. Strategically positioned within the lamina propria, CD103(+) DCs play an important role in maintaining intestinal immune homeostasis. These cells are required for the induction of tolerogenic immune responses and imprinting gut homing phenotypic changes on antigen-specific T cells. Recent insights into their development and regulatory properties have revealed additional immunoregulatory roles and further highlighted their importance for intestinal immunity. In this review we discuss the nature of the intestinal CD103(+) DC population and the emerging roles of these cells in the regulation of mucosal immunity. |
format | Online Article Text |
id | pubmed-3342356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33423562012-05-07 The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System Ruane, Darren Thomas Lavelle, Ed C. Front Immunol Immunology While dendritic cells (DC) are central to the induction and regulation of adaptive immunity, these cells are very heterogenous and specific subsets can be characterized based on the expression of cell surface markers and functional properties. Intestinal CD103(+) DCs are the subject of particular interest due to their role in regulating mucosal immunity. Since the epithelial surfaces are constantly exposed to a high antigenic load, tight regulation of innate and adaptive intestinal immune responses is vital as intestinal inflammation can have detrimental consequences for the host. Strategically positioned within the lamina propria, CD103(+) DCs play an important role in maintaining intestinal immune homeostasis. These cells are required for the induction of tolerogenic immune responses and imprinting gut homing phenotypic changes on antigen-specific T cells. Recent insights into their development and regulatory properties have revealed additional immunoregulatory roles and further highlighted their importance for intestinal immunity. In this review we discuss the nature of the intestinal CD103(+) DC population and the emerging roles of these cells in the regulation of mucosal immunity. Frontiers Research Foundation 2011-07-01 /pmc/articles/PMC3342356/ /pubmed/22566815 http://dx.doi.org/10.3389/fimmu.2011.00025 Text en Copyright © 2011 Ruane and Lavelle. http://www.frontiersin.org/licenseagreement This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with. |
spellingShingle | Immunology Ruane, Darren Thomas Lavelle, Ed C. The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System |
title | The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System |
title_full | The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System |
title_fullStr | The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System |
title_full_unstemmed | The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System |
title_short | The Role of CD103(+) Dendritic Cells in the Intestinal Mucosal Immune System |
title_sort | role of cd103(+) dendritic cells in the intestinal mucosal immune system |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342356/ https://www.ncbi.nlm.nih.gov/pubmed/22566815 http://dx.doi.org/10.3389/fimmu.2011.00025 |
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