Initiation of TCR Phosphorylation and Signal Transduction

Recent data with CD8+ T cells show that the initial phase of T cell receptor (TCR) binding to MHC–peptide (MHCp) is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data p...

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Autores principales: Gascoigne, Nicholas R. J., Casas, Javier, Brzostek, Joanna, Rybakin, Vasily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2011
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342367/
https://www.ncbi.nlm.nih.gov/pubmed/22566861
http://dx.doi.org/10.3389/fimmu.2011.00072
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author Gascoigne, Nicholas R. J.
Casas, Javier
Brzostek, Joanna
Rybakin, Vasily
author_facet Gascoigne, Nicholas R. J.
Casas, Javier
Brzostek, Joanna
Rybakin, Vasily
author_sort Gascoigne, Nicholas R. J.
collection PubMed
description Recent data with CD8+ T cells show that the initial phase of T cell receptor (TCR) binding to MHC–peptide (MHCp) is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the initial stage of TCR signaling that have not yet been clearly resolved. Firstly, how and by which Src-family kinase, is the initial phosphorylation of CD3ζ accomplished, given that the Lck associated with the co-receptors (CD4 or CD8) is not yet available. Secondly, what is the mechanism by which the co-receptor is brought close to the bound TCR before the co-receptor binds to MHCp?
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spelling pubmed-33423672012-05-07 Initiation of TCR Phosphorylation and Signal Transduction Gascoigne, Nicholas R. J. Casas, Javier Brzostek, Joanna Rybakin, Vasily Front Immunol Immunology Recent data with CD8+ T cells show that the initial phase of T cell receptor (TCR) binding to MHC–peptide (MHCp) is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the initial stage of TCR signaling that have not yet been clearly resolved. Firstly, how and by which Src-family kinase, is the initial phosphorylation of CD3ζ accomplished, given that the Lck associated with the co-receptors (CD4 or CD8) is not yet available. Secondly, what is the mechanism by which the co-receptor is brought close to the bound TCR before the co-receptor binds to MHCp? Frontiers Research Foundation 2011-12-07 /pmc/articles/PMC3342367/ /pubmed/22566861 http://dx.doi.org/10.3389/fimmu.2011.00072 Text en Copyright © 2011 Gascoigne, Casas, Brzostek and Rybakin. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Immunology
Gascoigne, Nicholas R. J.
Casas, Javier
Brzostek, Joanna
Rybakin, Vasily
Initiation of TCR Phosphorylation and Signal Transduction
title Initiation of TCR Phosphorylation and Signal Transduction
title_full Initiation of TCR Phosphorylation and Signal Transduction
title_fullStr Initiation of TCR Phosphorylation and Signal Transduction
title_full_unstemmed Initiation of TCR Phosphorylation and Signal Transduction
title_short Initiation of TCR Phosphorylation and Signal Transduction
title_sort initiation of tcr phosphorylation and signal transduction
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342367/
https://www.ncbi.nlm.nih.gov/pubmed/22566861
http://dx.doi.org/10.3389/fimmu.2011.00072
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AT casasjavier initiationoftcrphosphorylationandsignaltransduction
AT brzostekjoanna initiationoftcrphosphorylationandsignaltransduction
AT rybakinvasily initiationoftcrphosphorylationandsignaltransduction

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