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Autophagy and Mechanisms of Effective Immunity
Macroautophagy (autophagy) is a cellular pathway facilitating several critical functions. First, autophagy is a major pathway of degradation. It enables elimination of microbes that have invaded intracellular compartments. In addition, it promotes degradation of damaged cellular content, thereby act...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Research Foundation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342370/ https://www.ncbi.nlm.nih.gov/pubmed/22566941 http://dx.doi.org/10.3389/fimmu.2012.00060 |
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author | Mintern, Justine D. Villadangos, Jose A. |
author_facet | Mintern, Justine D. Villadangos, Jose A. |
author_sort | Mintern, Justine D. |
collection | PubMed |
description | Macroautophagy (autophagy) is a cellular pathway facilitating several critical functions. First, autophagy is a major pathway of degradation. It enables elimination of microbes that have invaded intracellular compartments. In addition, it promotes degradation of damaged cellular content, thereby acting to limit inflammatory signals. Second, autophagy is a major trafficking pathway, shuttling content between the cytosol and the lysosomal compartment. Given these two key roles, autophagy can have significant and sometimes unexpected consequences on mechanisms that initiate robust immunity. Here, we will discuss the impact of autophagy on pathways of innate and adaptive immune responses including microbe elimination, inflammatory cytokine production, antigen processing and T and B lymphocyte immunity. |
format | Online Article Text |
id | pubmed-3342370 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Research Foundation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33423702012-05-07 Autophagy and Mechanisms of Effective Immunity Mintern, Justine D. Villadangos, Jose A. Front Immunol Immunology Macroautophagy (autophagy) is a cellular pathway facilitating several critical functions. First, autophagy is a major pathway of degradation. It enables elimination of microbes that have invaded intracellular compartments. In addition, it promotes degradation of damaged cellular content, thereby acting to limit inflammatory signals. Second, autophagy is a major trafficking pathway, shuttling content between the cytosol and the lysosomal compartment. Given these two key roles, autophagy can have significant and sometimes unexpected consequences on mechanisms that initiate robust immunity. Here, we will discuss the impact of autophagy on pathways of innate and adaptive immune responses including microbe elimination, inflammatory cytokine production, antigen processing and T and B lymphocyte immunity. Frontiers Research Foundation 2012-04-04 /pmc/articles/PMC3342370/ /pubmed/22566941 http://dx.doi.org/10.3389/fimmu.2012.00060 Text en Copyright © 2012 Mintern and Villadangos. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
spellingShingle | Immunology Mintern, Justine D. Villadangos, Jose A. Autophagy and Mechanisms of Effective Immunity |
title | Autophagy and Mechanisms of Effective Immunity |
title_full | Autophagy and Mechanisms of Effective Immunity |
title_fullStr | Autophagy and Mechanisms of Effective Immunity |
title_full_unstemmed | Autophagy and Mechanisms of Effective Immunity |
title_short | Autophagy and Mechanisms of Effective Immunity |
title_sort | autophagy and mechanisms of effective immunity |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342370/ https://www.ncbi.nlm.nih.gov/pubmed/22566941 http://dx.doi.org/10.3389/fimmu.2012.00060 |
work_keys_str_mv | AT minternjustined autophagyandmechanismsofeffectiveimmunity AT villadangosjosea autophagyandmechanismsofeffectiveimmunity |