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T Helper1/T Helper2 Cells and Resistance/Susceptibility to Leishmania Infection: Is This Paradigm Still Relevant?
Work in large part on Leishmania major in the 1980s identified two distinct apparently counter-regulatory CD4(+) T cell populations, T helper (h)1 and Th2, that controlled resistance/susceptibility to infection respectively. However, the generation of IL-4(−/−) mice in the 1990s questioned the param...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Research Foundation
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342373/ https://www.ncbi.nlm.nih.gov/pubmed/22566961 http://dx.doi.org/10.3389/fimmu.2012.00080 |