The miR-106b-25 cluster targets Smad7, activates TGF-β signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer

The role of TGF-β signaling in tumorigenesis is paradoxical: it can be tumor suppressive or tumor promotional, depending on context. The metastatic regulator, Six1, was recently shown to mediate this switch, providing a novel means to explain this elusive “TGF-β paradox”. Herein, we identify a mecha...

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Detalles Bibliográficos
Autores principales: Smith, Anna L., Iwanaga, Ritsuko, Drasin, David J., Micalizzi, Douglas S., Vartuli, Rebecca L, Tan, Aik-Choon, Ford, Heide L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342483/
https://www.ncbi.nlm.nih.gov/pubmed/22286770
http://dx.doi.org/10.1038/onc.2012.11

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