Cargando…
PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction
BACKGROUND: Deterioration of left ventricular (LV) function after myocardial infarction (MI) is a major cause of heart failure. Myocardial perfusion performance may play an important role in deterioration or improvement in LV function after MI. The aim of this study was to evaluate the myocardial pe...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342486/ https://www.ncbi.nlm.nih.gov/pubmed/22410839 http://dx.doi.org/10.1007/s00259-012-2085-0 |
_version_ | 1782231696745168896 |
---|---|
author | Slart, Riemer H. J. A. Glauche, Julius Golestani, Reza Zeebregts, Clark J. Jansen, Jan W. Dierckx, Rudi A. J. O. Oudkerk, Matthijs Willems, Tineke P. Glaudemans, Andor W. J. M. Boersma, Hendrikus H. Tio, René A. |
author_facet | Slart, Riemer H. J. A. Glauche, Julius Golestani, Reza Zeebregts, Clark J. Jansen, Jan W. Dierckx, Rudi A. J. O. Oudkerk, Matthijs Willems, Tineke P. Glaudemans, Andor W. J. M. Boersma, Hendrikus H. Tio, René A. |
author_sort | Slart, Riemer H. J. A. |
collection | PubMed |
description | BACKGROUND: Deterioration of left ventricular (LV) function after myocardial infarction (MI) is a major cause of heart failure. Myocardial perfusion performance may play an important role in deterioration or improvement in LV function after MI. The aim of this study was to evaluate the myocardial perfusion reserve (MPR) and stress perfusion in deteriorating and non-deteriorating LV segments in patients after MI by PET and MRI, respectively. METHODS: Regional wall thickening of 352 segments in 22 patients was assessed at 4 and 24 months after MI by cardiac MRI. PET was performed to evaluate MPR and adenosine stress (13)N-ammonia perfusion 24 months after MI. Segments were divided into four groups according to deterioration or improvement in wall thickening. RESULTS: Normal functional segments at 4 months after MI that remained stable had a significantly higher mean MPR and mean stress perfusion PET value than deteriorated segments (p < 0.001). Furthermore, dysfunctional segments that improved had a significantly higher mean stress perfusion PET value than dysfunctional segments that remained dysfunctional (p < 0.001). CONCLUSION: This study demonstrated the additional value of myocardial perfusion assessment in relation to the functional integrity of the injured myocardium. Segmental functional LV improvement after MI was associated with better regional myocardial perfusion characteristics. Furthermore, the amount of wall thickening reduction was associated with regional myocardial perfusion abnormalities in patients after MI. |
format | Online Article Text |
id | pubmed-3342486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-33424862012-05-16 PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction Slart, Riemer H. J. A. Glauche, Julius Golestani, Reza Zeebregts, Clark J. Jansen, Jan W. Dierckx, Rudi A. J. O. Oudkerk, Matthijs Willems, Tineke P. Glaudemans, Andor W. J. M. Boersma, Hendrikus H. Tio, René A. Eur J Nucl Med Mol Imaging Original Article BACKGROUND: Deterioration of left ventricular (LV) function after myocardial infarction (MI) is a major cause of heart failure. Myocardial perfusion performance may play an important role in deterioration or improvement in LV function after MI. The aim of this study was to evaluate the myocardial perfusion reserve (MPR) and stress perfusion in deteriorating and non-deteriorating LV segments in patients after MI by PET and MRI, respectively. METHODS: Regional wall thickening of 352 segments in 22 patients was assessed at 4 and 24 months after MI by cardiac MRI. PET was performed to evaluate MPR and adenosine stress (13)N-ammonia perfusion 24 months after MI. Segments were divided into four groups according to deterioration or improvement in wall thickening. RESULTS: Normal functional segments at 4 months after MI that remained stable had a significantly higher mean MPR and mean stress perfusion PET value than deteriorated segments (p < 0.001). Furthermore, dysfunctional segments that improved had a significantly higher mean stress perfusion PET value than dysfunctional segments that remained dysfunctional (p < 0.001). CONCLUSION: This study demonstrated the additional value of myocardial perfusion assessment in relation to the functional integrity of the injured myocardium. Segmental functional LV improvement after MI was associated with better regional myocardial perfusion characteristics. Furthermore, the amount of wall thickening reduction was associated with regional myocardial perfusion abnormalities in patients after MI. Springer-Verlag 2012-03-13 2012 /pmc/articles/PMC3342486/ /pubmed/22410839 http://dx.doi.org/10.1007/s00259-012-2085-0 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Article Slart, Riemer H. J. A. Glauche, Julius Golestani, Reza Zeebregts, Clark J. Jansen, Jan W. Dierckx, Rudi A. J. O. Oudkerk, Matthijs Willems, Tineke P. Glaudemans, Andor W. J. M. Boersma, Hendrikus H. Tio, René A. PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction |
title | PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction |
title_full | PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction |
title_fullStr | PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction |
title_full_unstemmed | PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction |
title_short | PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction |
title_sort | pet and mri for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342486/ https://www.ncbi.nlm.nih.gov/pubmed/22410839 http://dx.doi.org/10.1007/s00259-012-2085-0 |
work_keys_str_mv | AT slartriemerhja petandmrifortheevaluationofregionalmyocardialperfusionandwallthickeningaftermyocardialinfarction AT glauchejulius petandmrifortheevaluationofregionalmyocardialperfusionandwallthickeningaftermyocardialinfarction AT golestanireza petandmrifortheevaluationofregionalmyocardialperfusionandwallthickeningaftermyocardialinfarction AT zeebregtsclarkj petandmrifortheevaluationofregionalmyocardialperfusionandwallthickeningaftermyocardialinfarction AT jansenjanw petandmrifortheevaluationofregionalmyocardialperfusionandwallthickeningaftermyocardialinfarction AT dierckxrudiajo petandmrifortheevaluationofregionalmyocardialperfusionandwallthickeningaftermyocardialinfarction AT oudkerkmatthijs petandmrifortheevaluationofregionalmyocardialperfusionandwallthickeningaftermyocardialinfarction AT willemstinekep petandmrifortheevaluationofregionalmyocardialperfusionandwallthickeningaftermyocardialinfarction AT glaudemansandorwjm petandmrifortheevaluationofregionalmyocardialperfusionandwallthickeningaftermyocardialinfarction AT boersmahendrikush petandmrifortheevaluationofregionalmyocardialperfusionandwallthickeningaftermyocardialinfarction AT tiorenea petandmrifortheevaluationofregionalmyocardialperfusionandwallthickeningaftermyocardialinfarction |