Cargando…

Use of Serum Homocysteine to Predict Cardiovascular Disease in Korean Men with or without Metabolic Syndrome

The aim of this study was to examine whether serum homocysteine (Hcy) levels correlated with cardiovascular disease (CVD) depending on the presence or absence of metabolic syndrome (MetS) in Korean men. We conducted a case-control study, including 138 CVD and 290 non-CVD age-matched control subjects...

Descripción completa

Detalles Bibliográficos
Autores principales: Kang, Ji Yeon, Park, Ill Keun, Lee, Ji Young, Sung, Sook Hee, Chang, Youn Koun, Park, Yoo Kyoung, Choi, Tae In
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342540/
https://www.ncbi.nlm.nih.gov/pubmed/22563214
http://dx.doi.org/10.3346/jkms.2012.27.5.500
_version_ 1782231706789478400
author Kang, Ji Yeon
Park, Ill Keun
Lee, Ji Young
Sung, Sook Hee
Chang, Youn Koun
Park, Yoo Kyoung
Choi, Tae In
author_facet Kang, Ji Yeon
Park, Ill Keun
Lee, Ji Young
Sung, Sook Hee
Chang, Youn Koun
Park, Yoo Kyoung
Choi, Tae In
author_sort Kang, Ji Yeon
collection PubMed
description The aim of this study was to examine whether serum homocysteine (Hcy) levels correlated with cardiovascular disease (CVD) depending on the presence or absence of metabolic syndrome (MetS) in Korean men. We conducted a case-control study, including 138 CVD and 290 non-CVD age-matched control subjects. The subjects were divided into four subgroups: 34 CVD/MetS, 104 CVD, 77 MetS, and 213 normal subgroups. The mean Hcy was significantly higher, whereas HDL and intake of vitamin B(1) and B(2) were lower in the CVD group (P < 0.05) than non-CVD group. When compared to the control group, subjects with CVD/MetS, CVD and MetS exhibited high Hcy levels, with the highest observed in the CVD/MetS subgroup (P < 0.001). Multivariate stepwise linear regression between CVD and markers of CVD showed Hcy significantly correlated with CVD (P < 0.05). To predict CVD based on Hcy, Hcy threshold of 11.72 µM in non-MetS subjects had an area under the curve (AUC) of 0.664 (95% CI 0.598-0.731). In MetS subjects, the AUC was 0.618 and Hcy threshold was 13.32 µM (95% CI 0.509-0.726). The results of our study show that the presence of MetS needs to be considered when using Hcy levels for predicting CVD.
format Online
Article
Text
id pubmed-3342540
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher The Korean Academy of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-33425402012-05-04 Use of Serum Homocysteine to Predict Cardiovascular Disease in Korean Men with or without Metabolic Syndrome Kang, Ji Yeon Park, Ill Keun Lee, Ji Young Sung, Sook Hee Chang, Youn Koun Park, Yoo Kyoung Choi, Tae In J Korean Med Sci Original Article The aim of this study was to examine whether serum homocysteine (Hcy) levels correlated with cardiovascular disease (CVD) depending on the presence or absence of metabolic syndrome (MetS) in Korean men. We conducted a case-control study, including 138 CVD and 290 non-CVD age-matched control subjects. The subjects were divided into four subgroups: 34 CVD/MetS, 104 CVD, 77 MetS, and 213 normal subgroups. The mean Hcy was significantly higher, whereas HDL and intake of vitamin B(1) and B(2) were lower in the CVD group (P < 0.05) than non-CVD group. When compared to the control group, subjects with CVD/MetS, CVD and MetS exhibited high Hcy levels, with the highest observed in the CVD/MetS subgroup (P < 0.001). Multivariate stepwise linear regression between CVD and markers of CVD showed Hcy significantly correlated with CVD (P < 0.05). To predict CVD based on Hcy, Hcy threshold of 11.72 µM in non-MetS subjects had an area under the curve (AUC) of 0.664 (95% CI 0.598-0.731). In MetS subjects, the AUC was 0.618 and Hcy threshold was 13.32 µM (95% CI 0.509-0.726). The results of our study show that the presence of MetS needs to be considered when using Hcy levels for predicting CVD. The Korean Academy of Medical Sciences 2012-05 2012-04-25 /pmc/articles/PMC3342540/ /pubmed/22563214 http://dx.doi.org/10.3346/jkms.2012.27.5.500 Text en © 2012 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kang, Ji Yeon
Park, Ill Keun
Lee, Ji Young
Sung, Sook Hee
Chang, Youn Koun
Park, Yoo Kyoung
Choi, Tae In
Use of Serum Homocysteine to Predict Cardiovascular Disease in Korean Men with or without Metabolic Syndrome
title Use of Serum Homocysteine to Predict Cardiovascular Disease in Korean Men with or without Metabolic Syndrome
title_full Use of Serum Homocysteine to Predict Cardiovascular Disease in Korean Men with or without Metabolic Syndrome
title_fullStr Use of Serum Homocysteine to Predict Cardiovascular Disease in Korean Men with or without Metabolic Syndrome
title_full_unstemmed Use of Serum Homocysteine to Predict Cardiovascular Disease in Korean Men with or without Metabolic Syndrome
title_short Use of Serum Homocysteine to Predict Cardiovascular Disease in Korean Men with or without Metabolic Syndrome
title_sort use of serum homocysteine to predict cardiovascular disease in korean men with or without metabolic syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342540/
https://www.ncbi.nlm.nih.gov/pubmed/22563214
http://dx.doi.org/10.3346/jkms.2012.27.5.500
work_keys_str_mv AT kangjiyeon useofserumhomocysteinetopredictcardiovasculardiseaseinkoreanmenwithorwithoutmetabolicsyndrome
AT parkillkeun useofserumhomocysteinetopredictcardiovasculardiseaseinkoreanmenwithorwithoutmetabolicsyndrome
AT leejiyoung useofserumhomocysteinetopredictcardiovasculardiseaseinkoreanmenwithorwithoutmetabolicsyndrome
AT sungsookhee useofserumhomocysteinetopredictcardiovasculardiseaseinkoreanmenwithorwithoutmetabolicsyndrome
AT changyounkoun useofserumhomocysteinetopredictcardiovasculardiseaseinkoreanmenwithorwithoutmetabolicsyndrome
AT parkyookyoung useofserumhomocysteinetopredictcardiovasculardiseaseinkoreanmenwithorwithoutmetabolicsyndrome
AT choitaein useofserumhomocysteinetopredictcardiovasculardiseaseinkoreanmenwithorwithoutmetabolicsyndrome