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Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis

Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease of the CNS whose pathogenesis remains largely unknown, and available therapies are rarely successful in reversing neurological deficits or stopping disease progression. Ongoing studies on MS and the widely used murine model...

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Autores principales: Passani, Maria B., Ballerini, Clara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342557/
https://www.ncbi.nlm.nih.gov/pubmed/22563309
http://dx.doi.org/10.3389/fnsys.2012.00032
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author Passani, Maria B.
Ballerini, Clara
author_facet Passani, Maria B.
Ballerini, Clara
author_sort Passani, Maria B.
collection PubMed
description Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease of the CNS whose pathogenesis remains largely unknown, and available therapies are rarely successful in reversing neurological deficits or stopping disease progression. Ongoing studies on MS and the widely used murine model of experimental autoimmune encephalomyelitis (EAE) are focused on the many components of this complex and heterogeneous neurodegenerative disease in the hope of providing a mechanism-based characterization of MS that will afford successful strategies to limit and repair the neuronal damage. Recently, histamine has been postulated to have a key regulatory role in EAE and MS pathogenesis. Histamine is a mediator of inflammation and immune responses, exerting its many actions through four G protein-coupled receptors (H(1,2,3,4)R) that signal through distinct intracellular pathways and have different therapeutic potentials as they vary in expression, isoform distribution, signaling properties, and function. Immune cells involved in MS/EAE, including dendritic cells (DCs) and T lymphocytes, express H(1)R, H(2)R and H(4)R, and histamine may have varying and counteracting effects on a particular cell type, depending on the receptor subtypes being activated. Here, we review evidence of the complex and controversial role of histamine in the pathogenesis of MS and EAE and evaluate the therapeutic potential of histaminergic ligands in the treatment of autoimmune diseases.
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spelling pubmed-33425572012-05-04 Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis Passani, Maria B. Ballerini, Clara Front Syst Neurosci Neuroscience Multiple sclerosis (MS) is a chronic inflammatory, neurodegenerative disease of the CNS whose pathogenesis remains largely unknown, and available therapies are rarely successful in reversing neurological deficits or stopping disease progression. Ongoing studies on MS and the widely used murine model of experimental autoimmune encephalomyelitis (EAE) are focused on the many components of this complex and heterogeneous neurodegenerative disease in the hope of providing a mechanism-based characterization of MS that will afford successful strategies to limit and repair the neuronal damage. Recently, histamine has been postulated to have a key regulatory role in EAE and MS pathogenesis. Histamine is a mediator of inflammation and immune responses, exerting its many actions through four G protein-coupled receptors (H(1,2,3,4)R) that signal through distinct intracellular pathways and have different therapeutic potentials as they vary in expression, isoform distribution, signaling properties, and function. Immune cells involved in MS/EAE, including dendritic cells (DCs) and T lymphocytes, express H(1)R, H(2)R and H(4)R, and histamine may have varying and counteracting effects on a particular cell type, depending on the receptor subtypes being activated. Here, we review evidence of the complex and controversial role of histamine in the pathogenesis of MS and EAE and evaluate the therapeutic potential of histaminergic ligands in the treatment of autoimmune diseases. Frontiers Media S.A. 2012-05-03 /pmc/articles/PMC3342557/ /pubmed/22563309 http://dx.doi.org/10.3389/fnsys.2012.00032 Text en Copyright © 2012 Passani and Ballerini. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
spellingShingle Neuroscience
Passani, Maria B.
Ballerini, Clara
Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis
title Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis
title_full Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis
title_fullStr Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis
title_full_unstemmed Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis
title_short Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis
title_sort histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342557/
https://www.ncbi.nlm.nih.gov/pubmed/22563309
http://dx.doi.org/10.3389/fnsys.2012.00032
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