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Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia

AIM: To determine regional differences in the incidence, incidence trends, and clinical presentation of type 1 diabetes in children under the age of 15 years in Croatia in a 9-year period (1995-2003). METHODS: We included the patients who had been diagnosed with the disease and had started the insul...

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Autores principales: Stipančić, Gordana, La Grasta Sabolić, Lavinia, Požgaj Šepec, Marija, Radica, Ana, Skrabić, Veselin, Severinski, Srećko, Kujundžić Tiljak, Mirjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Medical Schools 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342644/
https://www.ncbi.nlm.nih.gov/pubmed/22522992
http://dx.doi.org/10.3325/cmj.2012.53.141
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author Stipančić, Gordana
La Grasta Sabolić, Lavinia
Požgaj Šepec, Marija
Radica, Ana
Skrabić, Veselin
Severinski, Srećko
Kujundžić Tiljak, Mirjana
author_facet Stipančić, Gordana
La Grasta Sabolić, Lavinia
Požgaj Šepec, Marija
Radica, Ana
Skrabić, Veselin
Severinski, Srećko
Kujundžić Tiljak, Mirjana
author_sort Stipančić, Gordana
collection PubMed
description AIM: To determine regional differences in the incidence, incidence trends, and clinical presentation of type 1 diabetes in children under the age of 15 years in Croatia in a 9-year period (1995-2003). METHODS: We included the patients who had been diagnosed with the disease and had started the insulin treatment before they were 15 years old. Regional differences between eastern, central, and southern Croatia were observed. The gross incidence was expressed by the number of newly diagnosed type 1 diabetes patients in 100 000 children of the same age and sex per year, ie, for the 0-14 age group, and for the 0-4, 5-9, and 10-14 subgroups. RESULTS: The highest incidence was observed in southern Croatia (10.91 per 100 000/y) and the lowest in central Croatia (8.64 per 100 000/y), and in eastern Croatia the incidence was 8.93 per 100 000/y. All three regions showed a growing incidence trend, which was significant only in eastern and southern Croatia. There was 35.9% of patients with diabetic ketoacidosis in eastern Croatia, 41.7% in central Croatia, and 31.3% in southern Croatia. CONCLUSION: Croatian regions show differences in the incidence, incidence trends, and disease presentation of type 1 diabetes. A further follow-up is needed to establish whether the regional differences are a consequence of the population dynamics in the observed period or they will continue to exist, pointing to differences in environmental risk factors.
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spelling pubmed-33426442012-05-03 Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia Stipančić, Gordana La Grasta Sabolić, Lavinia Požgaj Šepec, Marija Radica, Ana Skrabić, Veselin Severinski, Srećko Kujundžić Tiljak, Mirjana Croat Med J Epidemiology AIM: To determine regional differences in the incidence, incidence trends, and clinical presentation of type 1 diabetes in children under the age of 15 years in Croatia in a 9-year period (1995-2003). METHODS: We included the patients who had been diagnosed with the disease and had started the insulin treatment before they were 15 years old. Regional differences between eastern, central, and southern Croatia were observed. The gross incidence was expressed by the number of newly diagnosed type 1 diabetes patients in 100 000 children of the same age and sex per year, ie, for the 0-14 age group, and for the 0-4, 5-9, and 10-14 subgroups. RESULTS: The highest incidence was observed in southern Croatia (10.91 per 100 000/y) and the lowest in central Croatia (8.64 per 100 000/y), and in eastern Croatia the incidence was 8.93 per 100 000/y. All three regions showed a growing incidence trend, which was significant only in eastern and southern Croatia. There was 35.9% of patients with diabetic ketoacidosis in eastern Croatia, 41.7% in central Croatia, and 31.3% in southern Croatia. CONCLUSION: Croatian regions show differences in the incidence, incidence trends, and disease presentation of type 1 diabetes. A further follow-up is needed to establish whether the regional differences are a consequence of the population dynamics in the observed period or they will continue to exist, pointing to differences in environmental risk factors. Croatian Medical Schools 2012-04 /pmc/articles/PMC3342644/ /pubmed/22522992 http://dx.doi.org/10.3325/cmj.2012.53.141 Text en Copyright © 2012 by the Croatian Medical Journal. All rights reserved. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Epidemiology
Stipančić, Gordana
La Grasta Sabolić, Lavinia
Požgaj Šepec, Marija
Radica, Ana
Skrabić, Veselin
Severinski, Srećko
Kujundžić Tiljak, Mirjana
Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia
title Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia
title_full Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia
title_fullStr Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia
title_full_unstemmed Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia
title_short Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia
title_sort regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in croatia
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342644/
https://www.ncbi.nlm.nih.gov/pubmed/22522992
http://dx.doi.org/10.3325/cmj.2012.53.141
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