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Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia
AIM: To determine regional differences in the incidence, incidence trends, and clinical presentation of type 1 diabetes in children under the age of 15 years in Croatia in a 9-year period (1995-2003). METHODS: We included the patients who had been diagnosed with the disease and had started the insul...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Croatian Medical Schools
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342644/ https://www.ncbi.nlm.nih.gov/pubmed/22522992 http://dx.doi.org/10.3325/cmj.2012.53.141 |
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author | Stipančić, Gordana La Grasta Sabolić, Lavinia Požgaj Šepec, Marija Radica, Ana Skrabić, Veselin Severinski, Srećko Kujundžić Tiljak, Mirjana |
author_facet | Stipančić, Gordana La Grasta Sabolić, Lavinia Požgaj Šepec, Marija Radica, Ana Skrabić, Veselin Severinski, Srećko Kujundžić Tiljak, Mirjana |
author_sort | Stipančić, Gordana |
collection | PubMed |
description | AIM: To determine regional differences in the incidence, incidence trends, and clinical presentation of type 1 diabetes in children under the age of 15 years in Croatia in a 9-year period (1995-2003). METHODS: We included the patients who had been diagnosed with the disease and had started the insulin treatment before they were 15 years old. Regional differences between eastern, central, and southern Croatia were observed. The gross incidence was expressed by the number of newly diagnosed type 1 diabetes patients in 100 000 children of the same age and sex per year, ie, for the 0-14 age group, and for the 0-4, 5-9, and 10-14 subgroups. RESULTS: The highest incidence was observed in southern Croatia (10.91 per 100 000/y) and the lowest in central Croatia (8.64 per 100 000/y), and in eastern Croatia the incidence was 8.93 per 100 000/y. All three regions showed a growing incidence trend, which was significant only in eastern and southern Croatia. There was 35.9% of patients with diabetic ketoacidosis in eastern Croatia, 41.7% in central Croatia, and 31.3% in southern Croatia. CONCLUSION: Croatian regions show differences in the incidence, incidence trends, and disease presentation of type 1 diabetes. A further follow-up is needed to establish whether the regional differences are a consequence of the population dynamics in the observed period or they will continue to exist, pointing to differences in environmental risk factors. |
format | Online Article Text |
id | pubmed-3342644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Croatian Medical Schools |
record_format | MEDLINE/PubMed |
spelling | pubmed-33426442012-05-03 Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia Stipančić, Gordana La Grasta Sabolić, Lavinia Požgaj Šepec, Marija Radica, Ana Skrabić, Veselin Severinski, Srećko Kujundžić Tiljak, Mirjana Croat Med J Epidemiology AIM: To determine regional differences in the incidence, incidence trends, and clinical presentation of type 1 diabetes in children under the age of 15 years in Croatia in a 9-year period (1995-2003). METHODS: We included the patients who had been diagnosed with the disease and had started the insulin treatment before they were 15 years old. Regional differences between eastern, central, and southern Croatia were observed. The gross incidence was expressed by the number of newly diagnosed type 1 diabetes patients in 100 000 children of the same age and sex per year, ie, for the 0-14 age group, and for the 0-4, 5-9, and 10-14 subgroups. RESULTS: The highest incidence was observed in southern Croatia (10.91 per 100 000/y) and the lowest in central Croatia (8.64 per 100 000/y), and in eastern Croatia the incidence was 8.93 per 100 000/y. All three regions showed a growing incidence trend, which was significant only in eastern and southern Croatia. There was 35.9% of patients with diabetic ketoacidosis in eastern Croatia, 41.7% in central Croatia, and 31.3% in southern Croatia. CONCLUSION: Croatian regions show differences in the incidence, incidence trends, and disease presentation of type 1 diabetes. A further follow-up is needed to establish whether the regional differences are a consequence of the population dynamics in the observed period or they will continue to exist, pointing to differences in environmental risk factors. Croatian Medical Schools 2012-04 /pmc/articles/PMC3342644/ /pubmed/22522992 http://dx.doi.org/10.3325/cmj.2012.53.141 Text en Copyright © 2012 by the Croatian Medical Journal. All rights reserved. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Epidemiology Stipančić, Gordana La Grasta Sabolić, Lavinia Požgaj Šepec, Marija Radica, Ana Skrabić, Veselin Severinski, Srećko Kujundžić Tiljak, Mirjana Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia |
title | Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia |
title_full | Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia |
title_fullStr | Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia |
title_full_unstemmed | Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia |
title_short | Regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in Croatia |
title_sort | regional differences in incidence and clinical presentation of type 1 diabetes in children aged under 15 years in croatia |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342644/ https://www.ncbi.nlm.nih.gov/pubmed/22522992 http://dx.doi.org/10.3325/cmj.2012.53.141 |
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